Voxilaprevir intermediate 4

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
GS9857 Intermediate 4
API & Intermediates
KUMI2F122
1360828-80-3

118159958
26685094
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Voxilaprevir intermediate 4
C9H15ClF2N2O3S
304.74
≥98%(HPLC)
White Solid

500mg,1g,5g,10g,25g,50g and 100g
-20°C Freezer
Voxilaprevir intermediate 4 (also known as GS9857 Intermediate 4) is a pharmaceutical intermediate for the synthesis of the Voxilaprevir, which is a hepatitis C virus (HCV) nonstructural (NS) protein 3/4A protease inhibitor. It is also used as intermedates for various pharmceuticals, such as Glecaprevir, Grazoprevir, Simeprevir and Ruzasvir, etc..
Efficacy of Sofosbuvir, Velpatasvir, and GS-9857 in Patients With Hepatitis C Virus Genotype 2, 3, 4, or 6 Infections in an Open-Label, Phase 2 Trial. [1]
Sofosbuvir, Velpatasvir, and Voxilaprevir for Previously Treated HCV Infection. [2]
Establishment of robust HCV genotype 4d, 5a, and 6a replicon systems. [3]
References:
[1] E.J.Gane, et al, Gastroenterology, 2016, 151(5), pp 902-909.
[2] M.Bourliere, et al, N. Engl. J. Med., 2017, 376(22), pp 2134-2146.
[3] G.Camus, et al, Virology, 2018, 514, pp 134-141.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not classified as a dangerous goods



NONH for all modes of transport

1. Product Specification
Available on request.
2. Safety Data Sheet
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