1-(benzyloxy)-4-(difluoromethyl)benzene

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Benzyl 4-(difluoromethyl)phenyl ether, 4-(Benzyloxy)benzal fluoride
Difluoromethylating Building Blocks
KUMI2F96
915799-67-6
MFCD18803519
54772391
11071077
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
1-(benzyloxy)-4-(difluoromethyl)benzene
C14H12F2O
234.24
≥98%
Colorless to White Solid
78-80°C
5g,10g,25g,50g,100g,200g and 500g
Store at 2-8°C temperature
1-(benzyloxy)-4-(difluoromethyl)benzene is a useful difluoromethyl building block for the synthesis of various pharmaceutical compounds, such as Mechanism-based inhibitors(MbIs) with their ability to inhibit sulfatases, Minimal self-immolative probe for multimodal fluoride detection, and so on.
Synthesis and evaluation of general mechanism-based inhibitors of sulfatases based on (difluoro)methyl phenyl sulfate and cyclic phenyl sulfamate motifs. [1]
Copper-Mediated Difluoromethylation of Aryl and Vinyl Iodides. [2]
Minimal Self-Immolative Probe for Multimodal Fluoride Detection. [3]
Pd-Catalyzed Transfer of Difluorocarbene. [4]
Access to Difluoromethylated Arenes by Pd-Catalyzed Reaction of Arylboronic Acids with Bromodifluoroacetate. [5]
Chlorodifluoromethane-triggered formation of difluoromethylated arenes catalysed by palladium. [6]
CF2H, a Hydrogen Bond Donor. [7]
Nickel‐Catalyzed Difluoromethylation of Arylboronic Acids with Bromodifluoromethane. [8]
References:
[1] S.R.Hanson, et al, Bioorg. Med. Chem., 2006, 14(24), pp 8386-8395.
[2] P.S.Fier, et al, J. Am. Chem. Soc., 2012, 134(12), pp 5524-5527.
[3] L.Cabrielli, et al, J. Org. Chem., 2016, 81(22), pp 10715-10720.
[4] X.Deng, et al, Org. Lett., 2016, 18(17), pp 4384-4387.
[5] Z.Feng, et al, Org. Lett., 2016, 18(1), pp 44-47.
[6] Z.Feng, et al, Nat. Chem., 2017, 9(9), pp 918-923.
[7] C.D. Sessler, et al, J. Am. Chem. Soc., 2017, 139(27), pp 9325-9332.
[8] X.Fu, et al, Chin. J. Chem., 2018, 36(2), pp 143-146.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302+H312+H332,H315,H319,H335
P261,P280,P271
29093090
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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