1-bromo-4-(1,1-difluoroethyl)benzene is a useful building block for the synthesis or modification of pharmaceutical compounds, e.g. Inhibitors of human immunodeficiency virus replication and inhibitors of kidney urea transporter UT-B.
Nanomolar potency and metabolically stable inhibitors of kidney urea transporter UT-B. 
Copper-Mediated Aromatic 1,1-Difluoroethylation with (1,1-Difluoroethyl)trimethylsilane (TMSCF2CH3). 
 M.O.Anderson, et al, J. Med. Chem., 2012, 55(12), pp 5942-5950..
 X.Li, et al, Chem. Asian J., 2016, 11(12), pp 1789-1792.