1-bromo-4-(1,1-difluoroethyl)benzene

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
1-[1,1-bis(fluoranyl)ethyl]-4-bromanyl-benzene
Difluoromethyl Building Blocks
KUMI2F69
1000994-95-5
MFCD11110333
45158847
15595823
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
1-bromo-4-(1,1-difluoroethyl)benzene
C8H7BrF2
221.05
≥95.0%
Colorless to Yellow Liquid
80-82°C/13 mmHg
1g,5g,10g,25g,50g and 100g
Store at room temperature
1-bromo-4-(1,1-difluoroethyl)benzene is a useful building block for the synthesis or modification of pharmaceutical compounds, e.g. Inhibitors of human immunodeficiency virus replication and inhibitors of kidney urea transporter UT-B.
Nanomolar potency and metabolically stable inhibitors of kidney urea transporter UT-B. [1]
Copper-Mediated Aromatic 1,1-Difluoroethylation with (1,1-Difluoroethyl)trimethylsilane (TMSCF2CH3). [2]
References:
[1] M.O.Anderson, et al, J. Med. Chem., 2012, 55(12), pp 5942-5950..
[2] X.Li, et al, Chem. Asian J., 2016, 11(12), pp 1789-1792.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H301,H315,H319
P301+P310,P305+P351+P338
2903.99.8090
UN2810 6.1/PG III

1. Product Specification
2. Safety Data Sheet
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