1-tert-butyl 2-methyl (2S)-4,4-difluoropyrrolidine-1,2-dicarboxylate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
N-Boc-4,4-Difluoro-L-proline methyl ester
Difluoromethylating Building Blocks
KUMI2F92
203866-17-5
MFCD03094918
11129200
7929016
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
1-tert-butyl 2-methyl (2S)-4,4-difluoropyrrolidine-1,2-dicarboxylate
C11H17F2NO4
265.26
≥98%(GC)
Colorless to Yellow Solid
41-46°C
5g,10g,25g,50g,100g,200g and 500g
Store at 2-8°C temperature
1-tert-butyl 2-methyl (2S)-4,4-difluoropyrrolidine-1,2-dicarboxylate is a useful building block for the synthesis of various pharmaceutical compounds, such as VLA-4 antagonists, Hepatitis B Virus (HBV) Capsid Inhibitors, etc..
Synthesis, biological evaluation, and pharmacokinetic study of prolyl-1-piperazinylacetic acid and prolyl-4-piperidinylacetic acid derivatives as VLA-4 antagonists. [1]
Remarkable enhancement in the DNA-binding ability of C2-fluoro substituted pyrrolo[2,1-c][1,4]benzodiazepines and their anticancer potential. [2]
Extended Structure–Activity Relationship and Pharmacokinetic Investigation of (4-Quinolinoyl)glycyl-2-cyanopyrrolidine Inhibitors of Fibroblast Activation Protein (FAP). [3]
Cationic Chiral Fluorinated Oxazaborolidines. More Potent, Second-Generation Catalysts for Highly Enantioselective Cycloaddition Reactions. [4]
Design and Synthesis of Orally Bioavailable 4-Methyl Heteroaryldihydropyrimidine Based Hepatitis B Virus (HBV) Capsid Inhibitors. [5]
References:
[1] J.Chiba, et al, Bioorg. Med. Chem., 2006, 14(8), pp 2725-2746.
[2] A.Kamal, et al, Bioorg. Med. Chem., 2009, 17(4), pp 1557-1572.
[3] K.Jansen, et al, J. Med. Chem., 2014, 57(7), pp 3053-3074.
[4] K.M.Reddy, et al, J. Am. Chem. Soc., 2016, 138(7), pp 2443-2453.
[5] Z.Qiu, et al, J. Med. Chem., 2016, 59(16), pp 7651-7666.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not a hazardous substance or mixture


2933998090
NONH for all modes of transport

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