2,2-difluoro-1-propanol

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
2,2-difluoropropan-1-ol, 2,2-difluoropropanol
Difluoromethyl Building Blocks
KUMI2F58
33420-52-9
 MFCD07782150
13394818
4949063
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
2,2-difluoro-1-propanol
C3H6F2O
96.08
≥95.0%
Colorless Liquid
101-102°C
1g,5g,10g,25g,50g and 100g
Store at room temperature
2,2-difluoro-1-propanol is a useful starting material and building block for the synthesis of various pharmaceutical compounds, e.g. Cannabinoid receptor ligands, GPR119 agonists and Neprilysin inhibitors, etc..
New bicyclic cannabinoid receptor-1 (CB1-R) antagonists. [1]
Practical selective hydrogenation of α-fluorinated esters with bifunctional pincer-type ruthenium(II) catalysts leading to fluorinated alcohols or fluoral hemiacetals. [2]
Investigating the Influence of (Deoxy)fluorination on the Lipophilicity of Non-UV-Active Fluorinated Alkanols and Carbohydrates by a New log P Determination Method. [3]
Practical Synthesis of Amides via Copper/ABNO-Catalyzed Aerobic Oxidative Coupling of Alcohols and Amines. [4]
References:
[1] P.A.Carpino, et al, Bioorg. Med. Chem. Lett., 2006, 16(3), pp 731-736.
[2] T.Otsuka, et al, J. Am. Chem. Soc., 2013, 135(26), pp 9600-9603.
[3] B.Linclau, et al, Angew. Chem. Int. Ed. Engl., 2016, 55(2), pp 674-678.
[4] S.L.Zultanski, et al, J. Am. Chem. Soc., 2016, 138(20), pp 6416-6419.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H226,H302,H315,H319,H335
P261,P305+P351+P338
2905.59.9890
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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