2,2-difluoro-5-formylbenzodioxole

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
2,2-Difluoro-1,3-benzodioxole-5-carboxaldehyde
Difluoromethylating Building Blocks
KUMI2F81
656-42-8
MFCD00792420
2736973
1369253
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
2,2-difluoro-5-formylbenzodioxole
C8H4F2O3
186.11
≥98.0%(GC)
Colorless to Yellow Liquid
103-105°C/20 mmHg
5g,10g,25g,50g,100g,200g and 500g
Store at room temperature
2,2-difluoro-5-formylbenzodioxole is a useful difluoromethylated building block for the synthesis of various benzodioxole-containing pharmaceutical active compounds, e.g. FAAH Inhibitor JNJ-42165279.
Analysis of stereoelectronic properties of camptothecin analogues in relation to biological activity. [1]
Synthesis, structure, DNA-binding properties, and cytotoxicity of ruthenium(II) polypyridyl complexes. [2]
Reductive amination by continuous-flow hydrogenation: Direct and scalable synthesis of a benzylpiperazine. [3]
Preclinical Characterization of the FAAH Inhibitor JNJ-42165279. [4]
References:
[1] K.A.Werbovetz, et al, Bioorg. Med. Chem., 2000, 8(7), pp 1741-1747.
[2] Y.J.Lin, et al, Chem. Biodivers., 2010, 7(7), pp 1770-1783.
[3] J.Lin, et al, Synth., 2012, 44(15), pp 2469-2473.
[4] J.M.Keith, et al, ACS Med. Chem. Lett., 2015, 6(12), pp 1204-1208.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P261,P305+P351+P338
2932990090
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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