2,2-Difluorocyclopropanecarboxylic acid is a key building block containing biologically active gem-Difluorocyclopropane group with various applications in medicinal chemistry. e.g. Its derivative (i.e. 2,2-difluorocyclopropanecarbonyl chloride) can be used in Friedel-Crafts reactions with various arenes to prepare aryl 2,2-difluorocyclopropyl ketones.
Fluorinated cyclopropanecarboxylic acids and their derivatives. 
Synthesis of gem-Difluorinated Cyclopropanes and Cyclopropenes: Trifluoromethyltrimethylsilane as a Difluorocarbene Source. 
Friedel-Crafts Reactions of 2,2-Difluorocyclopropanecarbonyl Chloride: Unexpected Ring-Opening Chemistry. 
Studies of 1-Amino-2,2-difluorocyclopropane-1-carboxylic Acid: Mechanism of Decomposition and Inhibition of 1-Aminocyclopropane-1-carboxylic Acid Deaminase.
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