2,2-Difluorocyclopropanecarboxylic acid

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem SID
Reaxys RN
2,2-difluorocyclopropane-1-carboxylic acid
Difluoromethylated Building Blocks
KUMI2F08
107873-03-0
MFCD04115828
24885817
3602105
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
2,2-Difluorocyclopropanecarboxylic acid
C4H4F2O2
122.07
≥98%
White to Pale Yellow Solid
60-65ºC
5g,10g,25g,50g,100g,250g,500g and 1kg
Store 2-8ºC(recommended)
2,2-Difluorocyclopropanecarboxylic acid is a key building block containing biologically active gem-Difluorocyclopropane group with various applications in medicinal chemistry. e.g. Its derivative (i.e. 2,2-difluorocyclopropanecarbonyl chloride) can be used in Friedel-Crafts reactions with various arenes to prepare aryl 2,2-difluorocyclopropyl ketones.
Fluorinated cyclopropanecarboxylic acids and their derivatives. [1]
Synthesis of gem-Difluorinated Cyclopropanes and Cyclopropenes: Trifluoromethyltrimethylsilane as a Difluorocarbene Source. [2]
Friedel-Crafts Reactions of 2,2-Difluorocyclopropanecarbonyl Chloride: Unexpected Ring-Opening Chemistry. [3]
Studies of 1-Amino-2,2-difluorocyclopropane-1-carboxylic Acid: Mechanism of Decomposition and Inhibition of 1-Aminocyclopropane-1-carboxylic Acid Deaminase. [4]
References:
[1] K.R. Gassen, et al, J.F.Chem.,1990, 49(1),pp 127-139.
[2] F. Wang, et al, Angew. Chem. Int. Ed., 2011, 50(31), pp 7153-7157.
[3] W.R.Dolbier, et al, J. Org. Chem., 2011, 76(9), pp 3450-3456.
[4] C.H.Liu, et al, Org. Lett. 2015, 17(13), pp 3342-3345.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H314
P280,P305+P351+P338,P310

UN 3261 8/PG II

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