2,2-Difluoropropan-1-amine hydrochloride is a useful building block for the synthesis of various difluoromethylated pharmaceutical compounds, such as HCV NS5B polymerase inhibitors, cannabinoid-1 receptor antagonist for the treatment of obesity, etc..
gem-Difluorination of Aminoalkynes via Highly Reactive Dicationic Species in Superacid HF−SbF5: Application to the Efficient Synthesis of Difluorinated Cinchona Alkaloid Derivatives. 
Discovery of 2-(2-chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one (PF-514273), a novel, bicyclic lactam-based cannabinoid-1 receptor antagonist for the treatment of obesity. 
The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase.
 A.Cantet, et al, J. Org. Chem., 2008, 73(7), pp 2875-2878.
 R.L.Row, et al, J. Med. Chem., 2009, 52(9), pp 2652-2656.
 K.J.Eastman, et al, MedChemComm., 2017, 8(4), pp 796-806.