2,2-Difluoropropan-1-amine hydrochloride

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
1-Amino-2,2-difluoropropane hydrochloride
Difluoromethylating Building Blocks
KUMI2F98
868241-48-9
MFCD06659051
2758355
14483340
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
2,2-Difluoropropan-1-amine hydrochloride
C3H8ClF2N
131.55
≥98%
White to Beige Solid
235-239°C
2g,5g,10g,25g,50g,100g,200g and 500g
Store at 2-8°C temperature
2,2-Difluoropropan-1-amine hydrochloride is a useful building block for the synthesis of various difluoromethylated pharmaceutical compounds, such as HCV NS5B polymerase inhibitors, cannabinoid-1 receptor antagonist for the treatment of obesity, etc..
gem-Difluorination of Aminoalkynes via Highly Reactive Dicationic Species in Superacid HF−SbF5:  Application to the Efficient Synthesis of Difluorinated Cinchona Alkaloid Derivatives. [1]
Discovery of 2-(2-chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one (PF-514273), a novel, bicyclic lactam-based cannabinoid-1 receptor antagonist for the treatment of obesity. [2]
The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase. [3]
References:
[1] A.Cantet, et al, J. Org. Chem., 2008, 73(7), pp 2875-2878.
[2] R.L.Row, et al, J. Med. Chem., 2009, 52(9), pp 2652-2656.
[3] K.J.Eastman, et al, MedChemComm., 2017, 8(4), pp 796-806.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P261,P280,P271
29214900
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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