2,2-difluoropropane-1,3-diol

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
2,2-difluoro-1,3-bis-hydroxy-propane, 2,2-Difluoro-1,3-dihydroxypropane
Difluoromethylating Building Blocks
KUMI2F93
428-63-7
MFCD16619633
95744
1734756
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
2,2-difluoropropane-1,3-diol
C3H6F2O2
112.08
≥97%
White to Orange Solid (or Viscous Liquid in higher temp.)
51-52°C
5g,10g,25g,50g,100g,200g and 500g
Store at 2-8°C temperature
2,2-difluoropropane-1,3-diol is a useful difluoromethylated building block for the synthesis of various pharmaceutical compounds, such as anti-viral and anti-HIV agents.
Synthesis and biological properties of some cyclic phosphotriesters derived from 2'-deoxy-5-fluorouridine. [1]
Synthesis, Oral Bioavailability Determination, and in vitro Evaluation of Prodrugs of the Antiviral Agent 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA). [2]
Design and synthesis of carbocyclic versions of furanoid nucleoside phosphonic Acid analogues as potential anti-hiv agents. [3]
References:
[1] R.N.Hunston, et al, J. Med. Chem., 1984, 27(4), pp 440-444.
[2] J.E.Jr. Starrett, et al, J. Med. Chem., 1994, 37(2), pp 1857-1864.
[3] E.Kim, et al, Nucleosides Nucleotides Nucleic Acids, 2011, 30(10), pp 798-813.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P271,P261,P280
29055998
NONH for all modes of transport

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