2-(difluoromethylsulfanyl)isoindole-1,3-dione

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
N-(difluoromethylthio)phthalimide
Difluoromethylthiolating Reagents
KUMI2F147
1805773-37-8

122212171
28536956
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
2-(difluoromethylsulfanyl)isoindole-1,3-dione
C9H5F2NO2S
229.20
≥98%
White to Slightly pale yellow Solid
115-116°C
5g,10g,25g,50g,100g,200g and 500g
Store at 2-8°C temperature
2-(difluoromethylsulfanyl)isoindole-1,3-dione is a powerful electrophilic difluoromethylthiolating reagent that allows the difluoromethylthiolation of a wide range of nucleophiles including aryl/vinyl boronic acids, alkynes, amines, thiols, β-ketoesters, and oxindoles and electron-rich heteroarenes such as indole, pyrrole, 1H-pyrrolo[2,3-b]pyridine, imidazo[1,2-a]pyridine, aminothiazole, isoxazole, and pyrazole under mild conditions.
N-Difluoromethylthiophthalimide: A Shelf-Stable, Electrophilic Reagent for Difluoromethylthiolation. [1]
Visible Light-Promoted Decarboxylative Di- A nd Trifluoromethylthiolation of Alkyl Carboxylic Acids. [2]
A Two-Step, One-Pot, and Multigram-Scale Synthesis of N-Difluoromethylthiophthalimide. [3]
Synergistic Catalysis for the Umpolung Trifluoromethylthiolation of Tertiary Ethers. [4]
References:
[1] D.Zhu, et al, J. Am. Chem. Soc., 2015, 137(33), pp 10547-10553.
[2] L.Candish, et al, Chem. Eur. J., 2016, 22(14), pp 4753-4756.
[3] D.Zhu, et al, Org. Process Res. Dev., 2017, 21(9), pp 1383-1387.
[4] W.Xu, et al, Angew. Chem. Int. Ed., 2018, 57(32), pp 10357-10361.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319
P264,P280,P305+P351+P338
2930902900
NONH for all modes of Transport

1. Product Specification
2. Safety Data Sheet
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