3,3-difluoroazetidine hydrochloride

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
3,3-difluoroazetidine hydrochloric acid
Difluoromethyl Building Blocks
KUMI2F54
288315-03-7
MFCD05663714
2758247
13912286
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
3,3-difluoroazetidine hydrochloride
C3H5F2N·HCl
129.54
≥98.0%
Colorless to Yellow Solid
138-143°C
1g,5g,10g,25g,50g and 100g
Store at room temperature
3,3-difluoroazetidine hydrochloride is a useful starting material and useful building block for the synthesis of various pharmaceutically active molecules, such as PI3K inhibitors, CB2 Receptor agonists, Thrombin inhibitors and bromodomain inhibitors, etc..
Novel acetylcholine and carbamoylcholine analogues: Development of a functionally selective α4β2 nicotinic acetylcholine receptor agonist. [1]
Tetrahydrochromenoimidazoles as potassium-competitive acid blockers (P-CABs): Structure-activity relationship of their antisecretory properties and their affinity toward the hERG channel. [2]
Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesity. [3]
Studies of CDK 8/19 inhibitors: Discovery of novel and selective CDK8/19 dual inhibitors and elimination of their CYP3A4 time-dependent inhibition potential. [4]
In Vivo and Mechanistic Studies on Antitumor Lead 7-Methoxy-4-(2-methylquinazolin-4-yl)-3,4-dihydroquinoxalin-2(1H)-one and Its Modification as a Novel Class of Tubulin-Binding Tumor-Vascular Disrupting Agents. [5]
Design, synthesis and pharmacological evaluation of new acyl sulfonamides as potent and selective Bcl-2 inhibitors. [6]
References:
[1] C.P.Hansen, et al, J. Med. Chem., 2008, 51(23), pp 7380-7395.
[2] A.M.Palmer, et al, J. Med. Chem., 2010, 53(9), pp 3645-3674.
[3] S.He, et al, Bioorg. Med. Chem. Lett., 2010, 20(15), pp 4399-4405.
[4] J.Fujimoto, et al, Bioorg. Med. Chem. Lett., 2017, 25(12), pp 3018-3033.
[6] M.Cui, et al, J. Med. Chem., 2017, 60(13), pp 5586-5598.
[6] X.Lin, et al, Bioorg. Med. Chem., 2018, 26(2), pp 443-454.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
H261,H305+H351+H338
2933.99.8090
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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