3,3-difluorocyclobutanamine hydrochloride

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
3,3-difluorocyclobutylamine hydrochloride
Difluoromethyl Building Blocks
KUMI2F70
637031-93-7
MFCD10001382
22500957
14200985
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay(Analysis Method)
Appearance
Melting Point
Packaging
Storage
3,3-difluorocyclobutanamine hydrochloride
C4H8ClF2N
143.56
≥98.0%(HPLC)
Colorless to White Solid
315°C
1g,5g,10g,25g,50g and 100g
Store at room temperature
3,3-difluorocyclobutanamine hydrochloride is a useful starting material and useful building block for the synthesis of various pharmaceutically active molecules, such as JAK inhibitors,HCV NS3 protease inhibitors, and mutant isocitric dehydrogenase 1 (IDH1) inhibitors, etc..
3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7 with efficacy in rat pain models. [1]
Discovery of novel HCV inhibitors: synthesis and biological activity of 6-(indol-2-yl)pyridine-3-sulfonamides targeting hepatitis C virus NS4B. [2]
Novel Quinoline-Based P2–P4 Macrocyclic Derivatives As Pan-Genotypic HCV NS3/4a Protease Inhibitors. [3]
Lead Optimization toward Proof-of-Concept Tools for Huntington's Disease within a 4-(1 H -Pyrazol-4-yl)pyrimidine Class of Pan-JNK Inhibitors. [4]
Discovery and structure-activity-relationship study of novel conformationally restricted indane analogues for mutant isocitric dehydrogenase 1 (IDH1) inhibitors. [5]
References:
[1] I.Macsari, et al, J. Med. Chem., 2012, 55(15), pp 6866-6880.
[2] X.Zhang, et al, Bioorg. Med. Chem. Lett., 2013, 23(13), pp 3947-3953.
[3] U.Shah, et al, ACS Med. Chem. Lett., 2014, 5(3), pp 264-269.
[4] J.Wityak, et al, J. Med. Chem., 2015, 58(7), pp 2967-2987.
[5] Q.Zhang, et al, Bioorg. Med. Chem. Lett., 2017, 27(25), pp 5262-5266.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302
P301+P312+P330
2921.30.9990
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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