3,3-difluorocyclobutanamine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
3,3-bis(fluoranyl)cyclobutan-1-amine,3,3-difluorocyclobutylamine
Difluoromethyl Building Blocks
KUMI2F53
791061-00-2
MFCD11869718
22500951
14228588
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay(Analysis Method)
Appearance
Melting Point
Packaging
Storage
3,3-difluorocyclobutanamine
C4H7F2N
107.10
≥98.0%(HPLC)
Colorless to White Solid
>300°C
1g,5g,10g,25g,50g and 100g
Store at room temperature
3,3-difluorocyclobutanamine is a useful starting material and useful building block for the synthesis of various pharmaceutically active molecules, such as JAK inhibitors,HCV NS3 protease inhibitors, AXL inhibitors, Sirtuin modulators, Glucose uptake inhibitors and casein kinase 1 δ/ε inhibitors, etc..
Optimization of Potent, Selective, and Orally Bioavailable Pyrrolodinopyrimidine-Containing Inhibitors of Heat Shock Protein 90. Identification of Development Candidate 2-Amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide. [1]
Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening. [2]
Discovery of novel HCV inhibitors: synthesis and biological activity of 6-(indol-2-yl)pyridine-3-sulfonamides targeting hepatitis C virus NS4B. [3]
Lead Optimization toward Proof-of-Concept Tools for Huntington's Disease within a 4-(1 H -Pyrazol-4-yl)pyrimidine Class of Pan-JNK Inhibitors. [4]
Discovery of Highly Potent, Selective, and Efficacious Small Molecule Inhibitors of ERK1/2. [5]
Carbazole-containing sulfonamides and sulfamides: Discovery of cryptochrome modulators as antidiabetic agents. [6]
References:
[1] L.Zehnder,et al, J. Med. Chem., 2011, 54(9), pp 3368-3385.
[2] D.K.Tosh, et al, J. Med. Chem., 2012, 55(9), pp 4297-4308.
[3] X.Zhang, et al, Bioorg. Med. Chem. Lett., 2013, 23(13), pp 3947-3953.
[4] J.Wityak, et al, J. Med. Chem., 2015, 58(7), pp 2967-2987.
[5] R. Li, et al, J. Med. Chem., 2015, 58(4), pp 1976-1991.
[6] P.S.Humphries, et al, Bioorg. Med. Chem. Lett., 2016, 26(3), pp 751-760.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302,H335
P261,P280,P305+P351+P338

NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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