3,3-Difluorocyclobutanecarboxylic Acid

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem SID
Reaxys RN
3,3-difluorocyclobutane-1-carboxylic acid
Difluoromethylating Reagents,Difluoromethyl Building Blocks
KUMI2F10
107496-54-8
MFCD08705857
329818307
4374849
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
3,3-Difluorocyclobutanecarboxylic Acid
C5H6F2O2
136.10
≥98%
White to Slightly pale yellow Solid
51-55ºC
5g,10g,25g,50g,100g and 500g
Store 2-8ºC(recommended)
3,3-Difluorocyclobutanecarboxylic Acid is a geminal difluorocycloputyl building block for preparation of pharmaceutically active molecules.
Synthesis and evaluation of 2-phenyl-1,4-butanediamine-based CCR5 antagonists for the treatment of HIV-1. [1]
Synthesis and Antiobesity Properties of 6-(4-Chlorophenyl)-3-(4-((3,3-difluoro-1-hydroxycyclobutyl)methoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one (BMS-814580): A Highly Efficacious Melanin Concentrating Hormone Receptor 1 (MCHR1) Inhibitor. [2]
Synthesis of Reversed C-Acyl Glycosides through Ni/Photoredox Dual Catalysis. [3]
References:
[1] M.D.Tallant, et al, Bioorg. Med. Chem. Lett., 2011, 21(5), pp 1394-1398.
[2] S.Ahmad, et al, J. Med. Chem., 2016, 59(19), pp 8848-8858..
[3] S.O.Badir, et al, Angew. Chem. Int. Ed. Engl., 2018, 57(22), pp 6610-6613.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302+H312,H315,H319,H335
P280,P301+P312+P330,P305+P351+P338
2916200090
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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