3,3-difluoropyrrolidine hydrochloride

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
3,3-difluoropyrrolidine HCL
Difluoromethyl Building Blocks
KUMI2F64
163457-23-6
MFCD03788948
2782826
9642778
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
3,3-difluoropyrrolidine hydrochloride
C4H8ClF2N
143.56
≥97.0%
White to Tan Solid
133-136°C
5g,10g,25g,50g,100g,250g,500g and 1kg
Store at room temperature
3,3-difluoropyrrolidine hydrochloride is a useful starting material and  building block for the synthesis or modification of pharmaceutical compounds, typically example of dipeptidyl peptidase IV inhibitors.
Fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors. [1]
Discovery of potent and selective orally bioavailable β-substituted phenylalanine derived dipeptidyl peptidase IV inhibitors. [2]
New fluorinated pyrrolidine and azetidine amides as dipeptidyl peptidase IV inhibitors. [3]
Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors. [4]
Substituted pyrrolidine-2,4-dicarboxylic acid amides as potent dipeptidyl peptidase IV inhibitors. [5]
Discovery and structure-Activity relationships of piperidinone- and piperidine-constrained phenethylamines as novel, potent, and selective dipeptidyl peptidase IV inhibitors. [6]
References:
[1] C.G.Caldwell, et al, Bioorg. Med. Chem. Lett., 2004, 14(5), pp 265-268.
[2] S.D.Edmondson, et al, Bioorg. Med. Chem. Lett., 2005, 15(12), pp 3048-3052.
[3] B.Hulin, et al, Bioorg. Med. Chem. Lett., 2005, 15(21), pp 4770-4773.
[4] J. Xu, et al, Bioorg. Med. Chem. Lett., 2006, 16(20), pp 5373-5377.
[5] T.Tsai, et al, Bioorg. Med. Chem. Lett., 2006, 16(12), pp 3268-3272.
[6] Z.Pei, et al, J. Med. Chem., 2007, 50(8), pp 1983-1987.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P261,P305+P351+P338
2933.99.8090
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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