3,3-difluoropyrrolidine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
3,3-difluoro-pyrrolidine, 3,3-bis(fluoranyl)pyrrolidine
Difluoromethyl Building Blocks
KUMI2F62
316131-01-8
MFCD09033654
2782827
9616674
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
3,3-difluoropyrrolidine
C4H7F2N
107.10
≥95.0%
Lqiuid

1g,5g,10g,25g,50g and 100g
Store at room temperature
3,3-difluoropyrrolidine is a useful starting material and  building block for the synthesis or modification of pharmaceutical compounds, typically example of dipeptidyl peptidase IV inhibitors.
Fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors. [1]
Discovery of potent and selective orally bioavailable β-substituted phenylalanine derived dipeptidyl peptidase IV inhibitors. [2]
New fluorinated pyrrolidine and azetidine amides as dipeptidyl peptidase IV inhibitors. [3]
Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors. [4]
Substituted pyrrolidine-2,4-dicarboxylic acid amides as potent dipeptidyl peptidase IV inhibitors. [5]
Discovery and structure-Activity relationships of piperidinone- and piperidine-constrained phenethylamines as novel, potent, and selective dipeptidyl peptidase IV inhibitors. [6]
References:
[1] C.G.Caldwell, et al, Bioorg. Med. Chem. Lett., 2004, 14(5), pp 265-268.
[2] S.D.Edmondson, et al, Bioorg. Med. Chem. Lett., 2005, 15(12), pp 3048-3052.
[3] B.Hulin, et al, Bioorg. Med. Chem. Lett., 2005, 15(21), pp 4770-4773.
[4] J. Xu, et al, Bioorg. Med. Chem. Lett., 2006, 16(20), pp 5373-5377.
[5] T.Tsai, et al, Bioorg. Med. Chem. Lett., 2006, 16(12), pp 3268-3272.
[6] Z.Pei, et al, J. Med. Chem., 2007, 50(8), pp 1983-1987.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H225
P280,P303+P361+p353,P370+P378

UN1993 3/PG III

1. Product Specification
2. Safety Data Sheet
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