4,4-difluorocyclohexanecarboxylic acid

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
4,4-difluorocyclohexane-1-carboxylic acid
Difluoromethyl Building Blocks
KUMI2F66
122665-97-8
MFCD03788493
2779136
10064166
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
4,4-difluorocyclohexanecarboxylic acid
C7H10F2O2
164.15
≥98.0%
White to Off-white Solid
103-107°C
1g,5g,10g,25g,50g and 100g
Store at room temperature
4,4-difluorocyclohexanecarboxylic acid is a useful , potential gem-diflurocyclohexane-containing building block for the synthesis of pharmaceutical compounds, e.g. Piperidone tachykinin antagonists,CCR5 inhibitors, mGluR5 positive allosteric modulators and Hepatitis C Virus inhibitors.
Evaluation of a 3-amino-8-azabicyclo[3.2.1]octane replacement in the CCR5 antagonist maraviroc. [1]
Azetidinyl oxadiazoles as potent mGluR5 positive allosteric modulators. [2]
Rational development of 4-aminopyridyl-based inhibitors targeting trypanosoma cruzi CYP51 as anti-chagas agents. [3]
Discovery of GS-9669, a thumb site II non-nucleoside inhibitor of NS5B for the treatment of genotype 1 chronic hepatitis C infection. [4]
The design and synthesis of potent and selective inhibitors of trypanosoma brucei glycogen synthase kinase 3 for the treatment of human African trypanosomiasis. [5]
Exploration of bivalent ligands targeting putative mu opioid receptor and chemokine receptor CCR5 dimerization. [6]
Fragment-based design, synthesis, biological evaluation, and SAR of 1H-benzo[d]imidazol-2-yl)-1H-indazol derivatives as potent PDK1 inhibitors. [7]
Structure Optimization of Aloperine Derivatives as HIV-1 Entry Inhibitors. [8]
Photoinduced, Copper-Catalyzed Decarboxylative C-N Coupling to Generate Protected Amines: An Alternative to the Curtius Rearrangement. [9]
References:
[1] R.C.Lemoine, et al, Bioorg. Med. Chem. Lett., 2010, 20(5), pp 1674-1676.
[2] M.Packiarajan, et al, Bioorg. Med. Chem. Lett., 2012, 22(20), pp 6469-6474.
[3] J.Y.Choi, et al , J. Med. Chem., 2013, 56(19), pp 7651-7658.
[4] S.E.Lazerwith, et al, J. Med. Chem., 2014, 57(5), pp 1893-1901..
[5] R.Urich, et al, J. Med. Chem., 2014, 57(18), pp 7536-7549.
[6] C.K.Arnatt, et al, Bioorg. Med. Chem. 2016, 24(22), pp 5969-5687.
[7] T.Chen, et al, Bioorg. Med. Chem. Lett., 2017, 27(24), pp 5473-5480.
[8] Z.Dang, et al, ACS Med. Chem. Lett., 2017, 8(11), pp 1199-1203.
[9] W.Zhao, et al, J. Am. Chem. Soc., 2017, 139(35), pp 12153-12153.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P261,P305+P351+P338
2916200090
NONH for all mode of transport

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