4,4-difluorocyclohexanecarboxylic acid is a useful , potential gem-diflurocyclohexane-containing building block for the synthesis of pharmaceutical compounds, e.g. Piperidone tachykinin antagonists,CCR5 inhibitors, mGluR5 positive allosteric modulators and Hepatitis C Virus inhibitors.
Evaluation of a 3-amino-8-azabicyclo[3.2.1]octane replacement in the CCR5 antagonist maraviroc. 
Azetidinyl oxadiazoles as potent mGluR5 positive allosteric modulators. 
Rational development of 4-aminopyridyl-based inhibitors targeting trypanosoma cruzi CYP51 as anti-chagas agents. 
Discovery of GS-9669, a thumb site II non-nucleoside inhibitor of NS5B for the treatment of genotype 1 chronic hepatitis C infection. 
The design and synthesis of potent and selective inhibitors of trypanosoma brucei glycogen synthase kinase 3 for the treatment of human African trypanosomiasis. 
Exploration of bivalent ligands targeting putative mu opioid receptor and chemokine receptor CCR5 dimerization. 
Fragment-based design, synthesis, biological evaluation, and SAR of 1H-benzo[d]imidazol-2-yl)-1H-indazol derivatives as potent PDK1 inhibitors. 
Structure Optimization of Aloperine Derivatives as HIV-1 Entry Inhibitors. 
Photoinduced, Copper-Catalyzed Decarboxylative C-N Coupling to Generate Protected Amines: An Alternative to the Curtius Rearrangement.