(4,4-difluorocyclohexyl)methanolis a useful, potential gem-diflurocyclohexane building block for the synthesis or modification of pharmaceutical compounds, e.g. Mu Opioid receptor antagonists, Nonpetidic cathespin S inhibitors, Tachykinin antagonists and Cannabinoid receptor ligands, etc.
4-Amino-2-cyanopyrimidines: Novel scaffold for nonpeptidic cathepsin S inhibitors.
Discovery of orally bioavailable cathepsin S inhibitors for the reversal of neuropathic pain. 
Discovery of bacterial NAD+-dependent DNA ligase inhibitors: Improvements in clearance of adenosine series. 
Fluorinated betulinic acid derivatives and evaluation of their anti-HIV activity. 
Potent α-amino-β-lactam carbamic acid ester as NAAA inhibitors. Synthesis and structure-activity relationship (SAR) studies.