(4,4-difluorocyclohexyl)methanol

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
4,4-difluorocyclohexane methanol, 4,4-Difluorocyclohexane-1-methanol
Difluoromethyl Building Blocks
KUMI2F65
178312-48-6
MFCD11847775
21184133
13832283
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
(4,4-difluorocyclohexyl)methanol
C7H12F2O
150.17
≥98.0%(GC)
Colorless to Yellow Liquid
207-213°C
1g,5g,10g,25g,50g and 100g
Store at room temperature
(4,4-difluorocyclohexyl)methanol is a useful, potential gem-diflurocyclohexane building block for the synthesis or modification of pharmaceutical compounds, e.g. Mu Opioid receptor antagonists, Nonpetidic cathespin S inhibitors, Tachykinin antagonists and Cannabinoid receptor ligands, etc.
4-Amino-2-cyanopyrimidines: Novel scaffold for nonpeptidic cathepsin S inhibitors. [1]
Discovery of orally bioavailable cathepsin S inhibitors for the reversal of neuropathic pain. [2]
Discovery of bacterial NAD+-dependent DNA ligase inhibitors: Improvements in clearance of adenosine series. [3]
Fluorinated betulinic acid derivatives and evaluation of their anti-HIV activity. [4]
Potent α-amino-β-lactam carbamic acid ester as NAAA inhibitors. Synthesis and structure-activity relationship (SAR) studies. [5]
A Chemical Probe for the ATAD2 Bromodomain. [6]
Development of Fluorinated Analogues of Perhexiline with Improved Pharmacokinetic Properties and Retained Efficacy. [7]
Identification of a 4-fluorobenzyl L-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT). [8]
References:
[1] O.Irie, et al, Bioorg. Med. Chem. Lett., 2008, 18(16), pp 4642-4646.
[2] O.Irie, et al, J. Med. Chem., 2008, 51(18), pp 5502-5505.
[3] S.S.Stokes, et al, Bioorg. Med. Chem. Lett., 2012, 22(1), pp 85-89.
[4] J.Li, et al, Bioorg. Med. Chem. Lett., 2016, 26(1), pp 68-71.
[5] A.Nuzzi, et al, Eur. J. Med. Chem., 2016, 111, pp 138-159.
[6] P.Bamborough, et al, Angew. Chem. Int. Ed. Engl., 2016, 55(38), pp 11382-11386.
[7] C.C. Tseng, et al, J. Med. Chem., 2017, 60(7), pp 2780-2789.
[8] T.Akama, et al, Bioorg. Med. Chem. Lett., 2018, 28(1), pp 6-10.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P261,P305+P351+P338
2906.19.0090
NONH for all mode of transport

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