8,8-difluoro-1,4-dioxaspiro[4,5]decane

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
4,4-difluorocyclohexanone ethylene acetal
Difluoromethyl Building Blocks
KUMI2F75
176251-49-3
MFCD11847478
22225014
14158853
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
8,8-difluoro-1,4-dioxaspiro[4,5]decane
C8H12F2O2
178.18
≥95.0%
White to Yellow Solid
48-49°C
5g,10g,25g,50g and 100g
Store at room temperature
8,8-difluoro-1,4-dioxaspiro[4,5]decane is a useful building block for the synthesis of fluorinating reagents and pharmaceutically active intermediates, such as Aminodifluorosulfinium Tetrafluoroborate salts( XtalFluor-E, deoxofluorinating reagent) and 1-Amino-4,4-difluorocyclohexanecarboxylic acid(a promising building block for drug discovery), etc..
Aminodifluorosulfinium Tetrafluoroborate salts as stable and crystalline deoxofluorinating reagents. [1]
Aminodifluorosulfinium salts: Selective fluorination reagents with enhanced thermal stability and ease of handling. [2]
Palladium Catalyzed Decarboxylative Rearrangement of N-Alloc Indoles. [3]
1-Amino-4,4-difluorocyclohexanecarboxylic acid as a promising building block for drug discovery: design, synthesis and characterization. [4]
Deoxofluorination reactions using N,N-disubstituted aminodifluorosulfinium tetrafluoroborate salts. [5]
References:
[1] F.Beaulieu, et al, Org. Lett., 2009, 11(21), pp 5050-5053.
[2] A.L'Herureux, et al, J. Org. Chem., 2010, 75(10), pp 3401-3411.
[3] J.Chen, et al, Org. Lett., 2013, 15(5), pp 1088-1091.
[4] P.K.Mykhailiuk, et al, Tetrahedron, 2013, 69(20), pp 4066-4075.
[5] O.Mahe, et al, J. F. Chem., 2013, 153, pp 57-60.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P261,P305+P351+P338
2932.99.0090
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
Please inquire for pricing and availability of this product by writing email to sales@kumidas.com.