An effective reagent to introduce difluoromethyl groups into carbonyls, imines, enamines, and alkyl halides. Not only various simple aldehydes and ketones, but also functionalized carbonyls such as α- and γ-ketoesters and cyclic imides can be difluoro(phenylthio)methylated in high yields under the activation of a catalytic amount of Lewis bases. The substitution reaction proceeds well with primary alkyl bromides and iodides as the limiting reactant when cesium fluorode/15-crown-5 is used as the fluoride source/additive.
Under radical conditions, the difluoro(phenylthio)methyl compounds containing vinyl functional groups can form 5- or 6-membered rings via intramolecular cyclization.
Stereoselective Difluoromethylenation Using Me3SiCF2SPh: Synthesis of Chiral 2,4-Disubstituted 3,3-Difluoropyrrolidine.
Fluoride-catalyzed addition of PhSCF2SiMe3 to N-substituted cyclic imides followed by radical cyclization: General synthetic strategy of gem-difluoromethylenated 1-azabicyclic compounds.
Reactions of sulfur- and phosphorus-substituted fluoroalkylating silicon reagents with imines and enamines under acidic conditions. 
Fluoride-catalyzed nucleophilic addition of PhSCF2SiMe3 to anhydrides: Synthesis of γ-difluoromethylated γ-lactams.
Stereoselective Nucleophilic Addition of PhSCF2SiMe3 to Chiral Cyclic Nitrones: Asymmetric Synthesis of gem-Difluoromethylenated Polyhydroxypyrrolizidines and -indolizidines.
 Y. Li, J. Hu, Angew. Chem. Int. Ed., 2007, 46(14), pp 2489-2492.
 T. Bootwicha, D. Panichakul, C. Kuhakarn, S. Prabpai, P. Kongsaeree, P. Tuchinda, V. Rentrakul, M. Pohmakotr, J.Org. Chem., 2009, 74(10), pp 3798-3805.
 M.D.Kosobokov, A.D.Dilman, M. I. Struchkova, P.A. Belyakov,J.Hu, J. Org. Chem., 2012,77(4),pp 2080-2086.
 V. Pharikronburee, T. Punirun,D. Soorukram, C. Kuhakarn,P. Tuchinda, V. Reutrakul, M. Pohmakotr, Org. Biomol. Chem., 2013, 11, pp 2022-2033.
 K.Korvorapun, D. Soorukram, C. Kuhakarn, P. Tuchinda, V. Reutrakul, M. Pohmakotr, Chem. : An Asian J., 2015, 10(4), pp 948-968.
UN 1993C 3/PG II
1. Product Specification
2. Safety Data Sheet
Please inquire for pricing and availability of this product by writing email firstname.lastname@example.org.