Difluoromethyl phenyl sulfone(PhSO2CF2H) can be used for nucleophilic difluoro(phenylsulfonyl)methylation of carbonyls, reductive silylation and the preparation of trifluoro- and difluoromethylsilanes, fluoroalkylation/chloroalkylation of α,β-enones, arynes, acetylenic ketones and other Michael acceptors and difluoromethylation of primary alkyl halides . It is also used in preparation of α-difluoromethyl amines, anti-difluoropropanediols, β-difluoromethylated and β-difluoromethylenated alcohols and amines, difluoroalkenes, difluoromethyl alcohol derivatives and fluoromethylated vicinal ethylenediamines.
Difluoromethyl Phenyl Sulfone as a Selective Difluoromethylene Dianion Equivalent: One-Pot Stereoselective Synthesis of anti-2,2-Difluoropropane-1,3-diols. 
Difluoromethyl phenyl sulfone, a difluoromethylidene equivalent: Use in the synthesis of 1,1-difluoro-1-alkenes.
Nucleophilic difluoromethylation of primary alkyl halides using difluoromethyl phenyl sulfone as a difluoromethyl anion equivalent. 
Convenient synthesis of difluoromethyl alcohols from both enolizable and non-enolizable carbonyl compounds with difluoromethyl phenyl sulfone. 
Stereoselective synthesis of Di- and monofluoromethylated vicinal ethylenediamines with Di- and monofluoromethyl sulfones.
Highly Diastereoselective Synthesis of α-Difluoromethyl Amines from N-tert-Butylsulfinyl Ketimines and Difluoromethyl Phenyl Sulfone. 
Radical (Phenylsulfonyl)difluoromethylation of Isocyanides with PhSO2CF2H under Transition-Metal-Free Conditions.