Ethyl 2,2-difluoro-2-phenylacetate is a difluoromethylated building block for discovery and synthesis of various pharmaceutically active compounds, such as EP4 receptor agonist. It is also employed as precursor for the preparation of fluorinating reagents.
Discovery and synthesis of a potent, selective and orally bioavailable EP4 receptor agonist.
Aromatic substitution with photochemically generated difluoromethyl radicals bearing electron-withdrawing group.
Photochemical substitution of olefins and aromatic compounds with difluoromethyl radicals bearing ester and phosphonate groups.
Asymmetric synthesis of β,β-difluoroamino acids via cross-coupling and Strecker reactions.
Tricomponent catalytic α,α-difluorination of acid chlorides.
Silver-Mediated C–H Difluoromethylation of Arenes.