Ethyl 2,2-difluoro-2-phenylacetate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
2,2-difluoro-2-phenylacetic acid ethyl ester
Difluoromethyl Building Blocks
KUMI2F74
2248-46-6
MFCD08275296
10631860
3277834
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
Ethyl 2,2-difluoro-2-phenylacetate
C10H10F2O2
200.18
≥98.0%
Colorless to Yellow Liquid
125-126°C/5 mmHg
5g,10g,25g,50g,100g,200g,500g and 1kg
Store at room temperature
Ethyl 2,2-difluoro-2-phenylacetate is a difluoromethylated building block for discovery and synthesis of various pharmaceutically active compounds, such as EP4 receptor agonist. It is also employed as precursor for the preparation of fluorinating reagents.
Discovery and synthesis of a potent, selective and orally bioavailable EP4 receptor agonist. [1]
Aromatic substitution with photochemically generated difluoromethyl radicals bearing electron-withdrawing group. [2]
Photochemical substitution of olefins and aromatic compounds with difluoromethyl radicals bearing ester and phosphonate groups. [3]
Asymmetric synthesis of β,β-difluoroamino acids via cross-coupling and Strecker reactions. [4]
Tricomponent catalytic α,α-difluorination of acid chlorides. [5]
Silver-Mediated C–H Difluoromethylation of Arenes. [6]
References:
[1] X.Billot, et al, Bioorg. Med. Chem. Lett., 2003, 13(6), pp 1129-1132.
[2] S.Murakami, et al , Synlett., 2004, 5, pp 815-818.
[3] S.Murakami, et al, Tetrahedron, 2006, 62(15), pp 3761-3769.
[4] X.Wang, et al, Tetrahedron, 2008, 64(8), pp 1731-1735.
[5] S.Bloom, et al, Org. Lett., 2011, 13(19), pp 5068-5071.
[6] J.Li, et al, Eur. J. Org. Chem., 2016, 28, pp 4916-4921.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P261,P271,P280
2915.39.00
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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