Ethyl 2,2-difluoropropanoate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
Ethyl 2,2-difluoropropionate, 2,2-difluoropropionic acid ethyl ester
Difluoromethyl Building Blocks
KUMI2F59
28781-85-3
MFCD06657970
2761188
2039793
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
Ethyl 2,2-difluoropropanoate
C5H8F2O2
138.11
≥98.0%
Colorless to Light yellow Liquid
110-115°C
1g,5g,10g,25g,50g and 100g
Store at room temperature
Ethyl 2,2-difluoropropanoate is a useful starting material and building block for the synthesis of various pharmaceutical compounds, e.g. Hepatitis C Virus Inhibitors and Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors.
Preparation and reaction of difluorinated malonaldehydic acid derivatives: a new route to functionalized α,α-difluorinated esters and amides. [1]
Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential. [2]
References:
[1] T.Tsukamoto, et al, J. Chem. Soc., Perkin Trans. 1, 1993, (10), pp 1177-1181.
[2] J.M.Coteron, et al, J. Med. Chem., 2011, 54(15), pp 5540-5561.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H226,H315,H319,H335
P261,P280,P305+P351+P338
2916.39.9000
UN3272 3/PG III

1. Product Specification
2. Safety Data Sheet
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