Ethyl 2,2-difluoropropanoate is a useful starting material and building block for the synthesis of various pharmaceutical compounds, e.g. Hepatitis C Virus Inhibitors and Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors.
Preparation and reaction of difluorinated malonaldehydic acid derivatives: a new route to functionalized α,α-difluorinated esters and amides. 
Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential. 
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