Difluoromethyl 2-pyridyl sulfone

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem SID
Reaxys RN
2-(Difluoromethylsulfonyl)pyridine, 2-PySO2CF2H, Hu Reagent
Difluoromethylating Reagents, Difluorocarbene Precursor
KUMI2F26
1219454-89-3
MFCD17010193 
329765740
20317604
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay(Analysis Method)
Appearance
Melting Point
Packaging
Storage
Difluoromethyl 2-pyridyl sulfone
C6H5F2NO2S
193.17
≥99%(HPLC)
White to Pale brown Solid
44-49ºC
5g,10g,25g,50g,100g,250g,500g and 1kg
Store at room temperature
Difluoromethyl 2-pyridyl sulfone(2-PySO2CF2H, Hu Reagent) is  a bench-stable nucleophilic reagent for difluoromethylation and gem-difluoroolefination of aldehydes and ketones, iododifluoromethylation of carbonyl compounds and difluoroalkylation of isocyanates and catalytic difluoromethylation of arylzincs. etc..
Difluoromethyl 2-pyridyl sulfone: a new gem-difluoroolefination reagent for aldehydes and ketones.  [1]
From difluoromethyl 2-pyridyl sulfone to difluorinated sulfonates: a protocol for nucleophilic difluoro(sulfonato)methylation[2]
Direct Synthesis of Fluorinated Heteroarylether Bioisosteres[3]
Gem-difluoroolefination of diaryl ketones and enolizable aldehydes with difluoromethyl 2-pyridyl sulfone:New insights into the Julia-Kocienski reaction. [4]
Highly Stereoselective Nucleophilic Addition of Difluoromethyl-2-pyridyl Sulfone to Sugar Lactones and Efficient Synthesis of Fluorinated 2-Ketoses[5]
Nucleophilic Difluoroalkylation of Isocyanates with Difluoromethyl 2-Pyridyl Sulfone.  [6]
Nucleophilic Iododifluoromethylation of Carbonyl Compounds Using Difluoromethyl 2-Pyridyl Sulfone. [7]
China's flourishing synthetic organofluorine chemistry: innovations in the new millennium. [8]
Iron-Catalyzed Difluoromethylation of Arylzincs with Difluoromethyl 2-Pyridyl Sulfone. [9]
References:
[1] Y.Zhao, et al  Org. Lett., 2010, 12(7), pp1444-1447.
[2] G. K. S. Prakash, et al, Angew. Chem. Int. Ed. Engl, 2011, 50(11), pp 2559-2563.
[3] Q. Zhou, et al, Angew. Chem. Int. Ed., 2013, 52(14), pp 3949-3952.
[4] B.Gao, et al, Eur. J. Chem., 2014, 20(25), pp 7803-7810.
[5] X.Liu, et al, Eur. J. Org. Chem., 2014, 2014(28), pp 6150-6154.
[6] S.Li, et al, Adv. Synth. Catal., 2015, 357(16-17), pp 3429-3434.
[7] W.Miao, et al, Org. Lett., 2016, 18(11), pp 2766-2769.
[8] Q.Liu, et al, Natl. Sci. Rev., 2017, 4(3), pp 302-325.
[9] W.Miao, et al, J. Am. Chem. Soc., 2018, 140(3), pp 880-883.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H301,H319
P301+P310,P305+P351+P338
2933.39.9100
UN 2811 6.1/PG III

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