Methyl 4,4-difluorocyclohexane-1-carboxylate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
4,4-difluoro-1-cyclohexanecarboxylic acid methyl ester
Difluoromethyl Building Blocks
KUMI2F73
121629-14-9
MFCD11040454
14365661
15139187
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
Methyl 4,4-difluorocyclohexane-1-carboxylate
C8H12F2O2
178.18
≥98.0%
White to Light-yellow Solid

5g,10g,25g,50g,100g,200g,500g and 1kg
Store at room temperature
Methyl 4,4-difluorocyclohexane-1-carboxylate is a difluoromethylated building block for discovery and synthesis of various pharmaceutically active compounds, e.g. sodium dependent glucose cotransporter(SGLT2) inhibitors and lactam based N-acylethanolamine acid amidase(NAAA) inhibitors. etc..
Potent α-amino-β-lactam carbamic acid ester as NAAA inhibitors. Synthesis and structure-activity relationship (SAR) studies. [1]
Iridium-Catalyzed Enantioselective Allylic Substitution of Aliphatic Esters with Silyl Ketene Acetals as the Ester Enolates. [2]
References:
[1] A.Nuzzi, et al, Eur. J. Med. Chem., 2016, 111, pp 138-159.
[2] X.Jiang, et al, Angew. Chem. Int. Ed., 2017, 56(30), pp 8887-8891.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P261,P305+P351+P338
2916.20.0090
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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