Methyl 4,4-difluorocyclohexane-1-carboxylate is a difluoromethylated building block for discovery and synthesis of various pharmaceutically active compounds, e.g. sodium dependent glucose cotransporter(SGLT2) inhibitors and lactam based N-acylethanolamine acid amidase(NAAA) inhibitors. etc..
Potent α-amino-β-lactam carbamic acid ester as NAAA inhibitors. Synthesis and structure-activity relationship (SAR) studies.
Iridium-Catalyzed Enantioselective Allylic Substitution of Aliphatic Esters with Silyl Ketene Acetals as the Ester Enolates.
 A.Nuzzi, et al, Eur. J. Med. Chem., 2016, 111, pp 138-159.