(R)-N-(tert-Butyl)dimethylsilyl-S-difluoromethyl-S-phenylsulfoximine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem SID
Reaxys RN

Difluoromethylating Reagents
KUMI2F17
1402352-49-1

329769113
23012511
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
(R)-N-(tert-Butyl)dimethylsilyl-S-difluoromethyl-S-phenylsulfoximine
C13H21F2NOSSi
305.46
≥98%(HPLC)
Colorless Solid

1g,5g,10g,50g and 100g
Store 2-8ºC (recommended)
A new chiral nucleophilic difluoromethylating reagent towards electrophiles such as aldehydes and ketones. Reductive desulfonimidoylation of the addition products with magnesium can afford difluoromethyl alcohols with high enantiopurity. This reagent is useful for the synthesis of enantioenriched difluoromethyl alcohols, especially the tertiary alcohols.
Tuning the reactivity of difluoromethyl sulfoximines from electrophilic to nucleophilic: Stereoselective nucleophilic difluoromethylation of aryl ketones.[1]
Reference:
[1] X. Shen, W. Zhang, C. Ni, Y. Gu, J. Hu, J. Am. Chem. Soc., 2012, 134(41), pp 16999-17002.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
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