(Triphenylphosphonio)difluoroacetate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
2,2-Difluoro-2-(triphenylphosphonio)acetate, Ph3P+CF2CO2-, PDFA
Difluorocarbene Reagents,Trifluoroethylating Reagents,F-Labeling Precursors
KUMI2F03
1449521-05-4
MFCD28359690
71812679 
8153047
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay(Analysis Method)
Appearance
Melting Point
Packaging
Storage
(Triphenylphosphonio)difluoroacetate
C20H15F2O2P
356.30
≥98% (HPLC)
Colorless to White Powder

1g,5g,10g,25g and 50g
Store locked-up, in a cool, well-ventilated place
(Triphenylphosphonio)difluoroacetate (Ph3P+CF2CO2-, PDFA) is a versatile and efficient difluorocarbene reagents for one pot, metal-free trifluoroethyl-ation, transition-metal-mediated trifluoromethylthiolation by sulfuration of difluorocarbene with elemental sulfur and  [18]F-labeling trifluoromethylthiol-ation with broad substrate scope and compatibility.
Conversion between Difluorocarbene and Difluoromethylene Ylide.[1]
Metal-Free Trifluoromethylation of Aromatic and Heteroaromatic Aldehydes and Ketones.[2]
Difluoromethylation of N-arylsulfonyl hydrazones with difluorocarbene leading to difluoromethyl arylsulfones.[3]
An Unconventional Mechanistic Insight into SCF3 Formation from Difluorocarbene: Preparation of 18 F-Labeled α-SCF3 Carbonyl Compounds.[4]
References:
[1] J. C Xiao et al, Chem. Eur. J. 2013, 19, pp 15261 – 15266.
[2] Y. Qiao, T. Si, M. H. Yang, R. A. Altman, J. Org. Chem., 2014, 79, pp 7122-7131.
[3] J. C Xiao et al, Royal S.Chem., 2016, 6, pp 82298-82300.
[4] J.Zhang, R.Cheng, J.H.Lin, D.H.Yu, L.Ma, L.Jia, L.Zhang, L.Wang, J.C. Xiao, S.H.Liang, Angew. Chem. Int. Ed. Engl., 2017,56(12), pp 3196-3200.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P261,P280,P305+P351+P338
2934.99.4400
NONH for all modes of transport
 
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