(Triphenylphosphonio)difluoroacetate (Ph3P+CF2CO2-, PDFA) is a versatile and efficient difluorocarbene reagents for one pot, metal-free trifluoroethyl-ation, transition-metal-mediated trifluoromethylthiolation by sulfuration of difluorocarbene with elemental sulfur and F-labeling trifluoromethylthiol-ation with broad substrate scope and compatibility.
Conversion between Difluorocarbene and Difluoromethylene Ylide.
Metal-Free Trifluoromethylation of Aromatic and Heteroaromatic Aldehydes and Ketones.
Difluoromethylation of N-arylsulfonyl hydrazones with difluorocarbene leading to difluoromethyl arylsulfones.
An Unconventional Mechanistic Insight into SCF3 Formation from Difluorocarbene: Preparation of 18 F-Labeled α-SCF3 Carbonyl Compounds.
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