(Bromodifluoromethyl)trimethylsilane (TMSCF2Br) is commonly employed as a novel dilfluorocarbene source for efficiently difluoromethylenating alkenes/alkynes and difluoromethylating O-,S-,N-,and P-nucleophiles. It may also be used in the preparation of gem-difluorocyclopropa(e)nes and as a precursor for synthesis of (chlorodifluoromethyl)trimethylsilane.
Synthesis of gem-Difluorocyclopropa(e)nes and O-,S-,N-, and P-Difluoromethylated Compounds with TMSCF2Br.
Nucleophilic Difluoromethylation Using (Bromodifluoromethyl)trimethylsilane.
Efficient Difluoromethylation of Alcohols Using TMSCF2Br as a Unique and Practical Difluorocarbene Reagent under Mild Conditions.