(Bromodifluoromethyl)trimethylsilane

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem SID
Reaxys RN
Bromodifluoro(trimethylsilyl)methane, BDFS,TMSCF2Br
Difluoromethylating Reagents, Difluorocarbene Precursor
KUMI2F22
115262-01-6
MFCD18641931
329769113
3535353
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Packaging
Storage
(Bromodifluoromethyl)trimethylsilane
C4H9BrF2Si
203.10
≥98%(GC)
Colorless Liquid
112ºC
5g,10g,25g,50g,100g,250g,500g and 1kg
Store at refrigerated condition(recommended)
(Bromodifluoromethyl)trimethylsilane (TMSCF2Br) is commonly employed as a novel dilfluorocarbene source for efficiently difluoromethylenating alkenes/alkynes and difluoromethylating O-,S-,N-,and P-nucleophiles. It may also be used in the preparation of gem-difluorocyclopropa(e)nes and as a precursor for synthesis of (chlorodifluoromethyl)trimethylsilane.
Synthesis of gem-Difluorocyclopropa(e)nes and O-,S-,N-, and P-Difluoromethylated Compounds with TMSCF2Br. [1]
Nucleophilic Difluoromethylation Using (Bromodifluoromethyl)trimethylsilane. [2]
Efficient Difluoromethylation of Alcohols Using TMSCF2Br as a Unique and Practical Difluorocarbene Reagent under Mild Conditions. [3]
References:
[1] L.Li, F.Wang,C.Ni, J.Hu, Angew. Chem. Int. Ed., 2013, 52(47), pp 12390-12394.
[2] A.L.Trifonov, A.A.Zemtsov, V.V.Levin, M.I. Struchkova, A.D.Dilman, Org. Lett., 2016, 18(14), pp 3458-3461.
[3] Q.Xie, C.Ni, R.Zhang, L. Li, J.Rong, J. Hu, Angew. Chem. Int. Ed., 2017, 56(12),pp 3206-3210.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H226,H315,H319,H335
P210,P305+P351+P338,P370+P378
2931900090
UN 1993 3/PG III

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