3-[3-hydroxymethylphenyl]-3-trifluoromethyl-3H-diazirine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
[3-[3-(trifluoromethyl)diazirin-3-yl]phenyl]methanol
Trifluoromethyl Building Blocks, Photoreactive Probe Building Blocks
KUMI3F70
176640-04-3

102404787
7639876
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay(Analysis Method)
Appearance
Boiling Point
Packaging
Storage
3-[3-hydroxymethylphenyl]-3-trifluoromethyl-3H-diazirine
C9H7F3N2O
216.16
≥98.0%(NMR,LC)
Pale Yellow to Yellow Clear Liquid

100mg,200mg,500mg,1g,5g and 10g
Store at 2-8°C
3-[3-hydroxymethylphenyl]-3-trifluoromethyl-3H-diazirine is a highly sensitive photo cross-linker containing photoreactive diazirine group for photoaffinity labeling to study ligand–receptor, ligand–enzyme and protein–protein interactions, and in the isolation and identification of unknown proteins.
A new cleavable carbene-generating reagent with 3-phenyl-3-trifluoromethyldiazirine photophore. [1]
Cross-linking chemistry and biology: development of multifunctional photoaffinity probes. [2]
Simple and Versatile Method for Tagging Phenyldiazirine Photophores. [3]
Recent Progress in Diazirine-Based Photoaffinity Labeling. [4]
Diazirine based photoaffinity labeling. [5]
References:
[1] Y. Hatanaka, U. Kempin, Y. Kanaoka, Heterocycles, 1998, 49(1), pp 464-468.
[2] T.Tomohiro, M.Hashimoto, Y.Hatanaka, Chem. Rec., 2005, 5(6), pp 385-395.
[3] H. Nakashima, M. Hashimoto, Y. Sadakane, T. Tomohiro, Y. hatanaka, J. Am. Chem. Soc., 2006, 128(47), pp 15092-15093.
[4] M. Hashimoto,Y.Hatanaka, Eur. J. Org. Chem., 2008, 15, pp 2513-2523.
[5] L. Dubinsky, B. P. Krom, M. M. Meijler, Bioorg. Med. Chem., 2012, 20(2), pp 554-570.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319
P264,P280,P305+P351+P338
2933.99.80900
NONH for all modes of transport

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