3-(Fluorosulfonyl)-2-thiophenecarboxylic acid methyl ester

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem SID
Reaxys RN
methyl 3-fluorosulfonylthiophene-2-carboxylate
Fluorinated Building Blocks, Probe Building Blocks
KUMI1F31
1373233-35-2
 
329772620

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Chemical Name
Molecular Formula
Molecular Weight
Assay(Analysis Method)
Appearance
Melting Point
Packaging
Storage
3-(Fluorosulfonyl)-2-thiophenecarboxylic acid methyl ester
C6H5FO4S2
224.23
≥95.0%(GC)
White to Begie Solid
75-80°C
1g,5g,10g,50g and 100g
Store at room temperature
Sulfonyl fluorides (SFs) have recently emerged as a promising warhead for the targeted covalent modification of proteins in drug discovery and Post-polymerization modification(PPM) in polymer science. Sulfonyl fluoride buidlding blocks can be used as a connector for the assembly of -SO2- linked small molecules with proteins or nucleic acids. This newly-defined click chemistry approach through sulfates is a complimentary approach to using amides and phosphate groups as linkers.
Sulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry. [1]
A study of the reactivity of S(VI)–F containing warheads with nucleophilic amino-acid side chains under physiological conditions. [2]
References:
[1] J.Dong,L.Krasnova,M.G.Finn,K.B.Sharpless, Angew. Chem. Int. Ed., 2014, 53(36), PP 9430-9448.
[2] H.Mukherjee,J.Debreczeni,J.Breed,S.Tentarelli,B.Aquila,J.E.Dowling,A.Whitty,N.P.Grimster, Org.Biomol.Chem., 2017, 15(45), pp 9685-9695.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H314
P280,P301+P361+P353,P304+P340+P310,P305+P351+338

UN 3261 8 / PGII

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