Ethenesulfonyl fluoride

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem SID
Reaxys RN
Vinyl sulfonyl fluoride, ESF
Fluorinated Building Blocks, Probe Building Blocks
KUMI1F35
677-25-8
MFCD00051388
329765803
1743083
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay(Analysis Method)
Appearance
Boiling Point
Packaging
Storage
Ethenesulfonyl fluoride
C2H3FO2S
110.11
≥96.0%(GC)
Colorless to Pale yellow
120-125°C
1g,2g,5g and 10g
Store at room temperature
Ethenesulfonyl fluoride(ESF) is a strong Michael acceptor for N, O, S, and C nucleophiles, as well as Diels-Alder dienophile. Taking use of ESF, facile incorporation of the SO2F functional group into molecules can be carried out with high yields for drug discovery and chemical biology application. The generated sulfonyl fluoride derivative is extremely stable but readily reacts with nucleophiles under the appropriate conditions for further functionalization or biochemical use.
Sulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry. [1]
Ethenesulfonyl Fluoride: The Most Perfect Michael Acceptor Ever Found?  [2]
Ethenesulfonyl Fluoride (ESF): An On-Water Procedure for the Kilogram-Scale Preparation. [3]
References:
[1] J. Dong, L. Krasnova, M. G. Finn, K. B. Sharpless, Angew. Chem. Int. Ed., 2014, 53(36), PP 9430-9448.
[2] Q. Chen, P. Mayer, H. Mayr, Angew. Chem. Int. Ed., 2016, 55(41), pp 12664-12667.
[3]  Q. Zheng, J. Dong, K. B. Sharpless, J. Org. Chem., 2016, 81(22), pp 11360-1362.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H226,H301+H311+H331,H314,H335,H341
P261,P280,P301+P310,P305+P351+338,P310

UN 2920 3(8) / PGII

1. Product Specification
2. Safety Data Sheet
Please inquire for pricing and availability of this product by writing email to sales@kumidas.com.