3-(3-methoxyphenyl)-3-(trifluoromethyl)diazirine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
3-(3-methoxyphenyl)-3-(trifluoromethyl)-3H-diazirine
Trifluoromethyl Building Blocks, Photoreactive Probe Building Blocks
KUMI3F159
205485-24-1

10465882
6649619
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay(Analysis Method)
Appearance
Boiling Point
Packaging
Storage
3-(3-methoxyphenyl)-3-(trifluoromethyl)diazirine
C9H7F3N2O
216.16
≥97%
Pale Yellow to Yellow Oily Liquid
43°C/1.8 Torr.
100mg,200mg,500mg,1g,5g and 10g
Store at 2-8°C
3-(3-methoxyphenyl)-3-(trifluoromethyl)diazirine is a highly sensitive photo cross-linker containing photoreactive diazirine group for photoaffinity labeling to study ligand–receptor, ligand–enzyme and protein–protein interactions, and in the isolation and identification of unknown proteins.
A Novel Family of Aromatic Diazirines for Photoaffinity Labeling. [1]
Simple method for the introduction of iodo-label on (3-trifluoromethyl) phenyldiazirine for photoaffinity labeling. [2]
Regiochemical Substituent Switching of Spin States in Aryl(trifluoromethyl)carbenes. [3]
A photoreactive probe that differentiates the binding sites of noncompetitive GABA receptor antagonists. [4]
Photoactivation of (p‐Methoxyphenyl)(trifluoromethyl)diazirine in the Presence of Phenolic Reaction Partners. [5]
Synthesis of Methoxy-Substituted Diazirinyl Phenylalanine – A Novel Photoreactive Aspartame Derivative for Functional Analysis of Sweet Receptors. [6]
Quantum chemical calculation of 19F NMR chemical shifts of trifluoromethyl diazirine photoproducts and precursors. [7]
Alternative One-Pot Synthesis of (Trifluoromethyl)phenyldiazirines from Tosyloxime Derivatives: Application for New Synthesis of Optically Pure Diazirinylphenylalanines for Photoaffinity Labelings. [8]
References:
[1] Y.Hatanaka, et al, J. Org. Chem., 1994, 59(2), pp 383-387.
[2] M.Hashimoto, et al, Tetrahedron Lett., 2006, 47(20), pp 3391-3394.
[3]  M.Song, et al, J. Am. Chem. Soc., 2011, 133(49), pp 19688-19690.
[4] H.Shimotahira, et al, Bioorg. Med. Chem. Lett., 2011, 21(6), pp 1598-1600.
[5] B.Raimer, et al, Chem. Eur. J., 2013, 19(21), pp 6551-6555.
[6] M.Sakurai, et al, Heterocycles, 2014, 88(1), pp 629-637.
[7] B.Raimer, et al, J. F. Chem., 2014, 166, pp 8-14.
[8] L.Wang, et al, Org. Lett., 2015, 17(3), pp 616-619.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H315,H319
P264,P280,P305+P351+P338

UN3265 8 / PG III

1. Product Specification
2. Safety Data Sheet
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