1,2-difluoro-4-methylbenzene is used to generate benzyne radical cations (3,4-difluorobenzyl radical cation) for the synthesis of the corresponding compounds, e.g. 2,3-difluorophenyl-linker-containing PARP1 inhibitors.
Effects of Aromatic Substitutions on the Photoreactions in Mg•+(C6HnF2X4-n) (X = F, CH3) Complexes: Formation and Decomposition of Benzyne Radical Cations.
C−C Coupling of Benzyl Fluorides Catalyzed by an Electrophilic Phosphonium Cation. 
Discovery, mechanism and metabolism studies of 2,3-difluorophenyl-linker-containing PARP1 inhibitors with enhanced in vivo efficacy for cancer therapy. 
 H.Liu, et al, J. Phys. Chem. A., 2004, 108(16), pp 3356-3366.