1,2-difluoro-4-methylbenzene

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
3,4-difluorotoluene
Fluorinated Building Blocks
KUMI2F107
2927-34-6
MFCD00075087
2733400
4175915
Chemical Name
Molecular Formula
Molecular Weight
Assay(Analysis Method)
Appearance
Boiling Point
Packaging
Storage
1,2-difluoro-4-methylbenzene
C7H6F2
128.12
≥99%(GC)
Colorless Liquid
110-113°C
5g,10g,50g,100g,200g and 500g
Store at 2-8°C temperature
1,2-difluoro-4-methylbenzene is used to generate benzyne radical cations (3,4-difluorobenzyl radical cation) for the synthesis of the corresponding compounds, e.g. 2,3-difluorophenyl-linker-containing PARP1 inhibitors.
Effects of Aromatic Substitutions on the Photoreactions in Mg•+(C6HnF2X4-n) (X = F, CH3) Complexes:  Formation and Decomposition of Benzyne Radical Cations. [1]
C−C Coupling of Benzyl Fluorides Catalyzed by an Electrophilic Phosphonium Cation. [2]
Discovery, mechanism and metabolism studies of 2,3-difluorophenyl-linker-containing PARP1 inhibitors with enhanced in vivo efficacy for cancer therapy. [3]
References:
[1] H.Liu, et al, J. Phys. Chem. A., 2004, 108(16), pp 3356-3366.
[2] J.Zhu, et al, Angew. Chem. Int. Ed., 2016, 55(29), pp 8448-8451.
[3] W.Chen, et al, Eur. J. Med. Chem., 2017, 138, pp 514-531.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H225
P210
2903998090
UN 1993 3/PG II

1. Product Specification
2. Safety Data Sheet
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