(1R,2S)-2-(3,4-difluorophenyl)-cyclopropanaminium (2R)-hydroxy(phenyl)ethanoate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine R-mandelate
Fluorinated Building Blocks, Fluorinated API & Intermediates
KUMI2F87
376608-71-8
MFCD21362980
9944965
14113750
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay(Analysis Method)
Appearance
Melting Point
Packaging
Storage
(1R,2S)-2-(3,4-difluorophenyl)-cyclopropanaminium (2R)-hydroxy(phenyl)ethanoate
C17H17F2NO3
321.32
≥98.0%(HPLC)
White to Off-white Solid
158-164°C
5g,10g,50g,100g,500g and1kg
Store at 2-8°C(recommended)
(1R,2S)-2-(3,4-difluorophenyl)-cyclopropanaminium (2R)-hydroxy(phenyl)ethanoate is an intermediate in the preparation of Ticagrelor, which is orally active reversible P2Y12 receptor antagonists for the prevention of thrombotic events (for example stroke or heart attack) in people with acute coronary syndrome or myocardial infarction with ST elevation.
From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis. [1]
Reference:
[1] B.Springthorpe, et al, Bioorg. Med. Chem. Lett., 2007, 17(21), pp 6013-6018.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Not a dangerous goods



NONH for all modes of transport

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