(1R,2S)-2-Fluorocyclopropanamine 4-methylbenzenesulfonate

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
(1R,2S)-2-fluorocyclopropylamine p-toluenesulfonic acid salt
Fluorinated Building Blocks
KUMI1F183
143062-84-4
MFCD01861147

PubChem ID

PubChem ID

PubChem ID

PubChem ID
53350313

Reaxys ID

Reaxys ID

Reaxys ID
5487378  
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
(1R,2S)-2-Fluorocyclopropanamine 4-methylbenzenesulfonate
C10H14FNO3S
247.28
98%(HPLC)
White to Off-white Solid
178-179°C
5g,10g,20g,50g,100g,200g and 500g
Store at room temperature
(1R,2S)-2-Fluorocyclopropanamine 4-methylbenzenesulfonate is a racemic monofluorinated three-member ring buidling block for the synthesis of Sitafloxacin (also called DU-6859), which is fluoroquinolone antibiotic that show promise in the treatment of buruli ulcer.
Synthetic studies on the key component of the new generation of quinolonecarboxylic acid, DU-6859. 1. Synthesis of (1R,2S)-2-fluorocyclopropylamine by the use of optical resolution. [1]
Design, synthesis and biological evaluations of novel 7-[3-(1-aminocycloalkyl)pyrrolidin-1-yl]-6-desfluoro-8-methoxyquinolones with potent antibacterial activity against multi-drug resistant Gram-positive bacteria. [2]
Synthesis, antimycobacterial and antibacterial evaluation of l-[(1R, 2S)-2-fluorocyclopropyl]fluoroquinolone derivatives containing an oxime functional moiety. [3]
References:
[1] O.Tamura, et al, Tetrahedron, et al, 1994, 50(13), pp 3889-3904.
[2] R.Miyauchi, et al, Bioorg. Med. Chem., 2009, 17(19), pp 6879-6889.
[3] H.Liu, et al, Eur. J. Med. Chem., 2014, 86, pp 628-638.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P271,P280
2921309990
NONH for all modes of transport.

1. Product Specification
2. Safety Data Sheet
Please inquire for pricing and availability of this product by writing email to sales@kumidas.com.