(1S,2R)-2-fluorocyclopropanamine 4-methylbenzenesulfonate is a racemic monofluorinated three-member ring buidling block for the synthesis of Sitafloxacin (also called DU-6859), which is fluoroquinolone antibiotic that show promise in the treatment of buruli ulcer.
Synthetic studies on the key component of the new generation of quinolonecarboxylic acid, DU-6859. 1. Synthesis of (1R,2S)-2-fluorocyclopropylamine by the use of optical resolution.
Design, synthesis and biological evaluations of novel 7-[3-(1-aminocycloalkyl)pyrrolidin-1-yl]-6-desfluoro-8-methoxyquinolones with potent antibacterial activity against multi-drug resistant Gram-positive bacteria.
Synthesis, antimycobacterial and antibacterial evaluation of l-[(1R, 2S)-2-fluorocyclopropyl]fluoroquinolone derivatives containing an oxime functional moiety.
 O.Tamura, et al, Tetrahedron, et al, 1994, 50(13), pp 3889-3904.