2-(2,5-difluorophenyl)acetic acid

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
2,5-Difluorophenylacetic acid, 2-[2,5-bis(fluoranyl)phenyl]ethanoic acid
Fluorinated Building Blocks
KUMI2F111
85068-27-5
MFCD00010000
522823
6844956
Chemical Name
Molecular Formula
Molecular Weight
Assay(Analysis Method)
Appearance
Melting Point
Packaging
Storage
2-(2,5-difluorophenyl)acetic acid
C8H6F2O2
172.13
≥97%
White Solid
126-128°C
5g,10g,50g,100g,200g,500g and 1kg
Store at 2-8°C temperature
2-(2,5-difluorophenyl)acetic acid is a heterocyclic fluorinated building block for the synthesis of various pharmaceutical compounds, such as PERK inhibitors, GPR88 Agonists, etc..
Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro- 1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK). [1]
Electrochemical direct carboxylation of benzyl alcohols having an electron-withdrawing group on the phenyl ring: one-step formation of phenylacetic acids from benzyl alcohols under mild conditions. [2]
Design, synthesis and pharmacological evaluation of 4-hydroxyphenylglycine and 4-hydroxyphenylglycinol derivatives as GPR88 agonists. [3]
References:
[1] J.M.Axten, et al, J. Med. Chem., 2012, 55(16), pp 7193-7207.
[2] H.Senboku, et al, Tetrahedron Lett., 2015, 56(48), pp 6772-6776.
[3] C.Jin, et al, Bioorg. Med. Chem., 2017, 25(2), pp 805-812.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P261,P305+P351+P228
2916.39.4600
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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