2,5-difluoropyridine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
2,5-bis(fluoranyl)pyridine
Fluorinated Building Blocks
KUMI2F105
84476-99-3
MFCD04114191
2762871
6474989
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay(Analysis Method)
Appearance
Boiling Point
Packaging
Storage
2,5-difluoropyridine
C5H3F2N
115.08
≥98%
Colorless to Yellow Liquid
115°C
5g,10g,50g,100g,200g and 500g
Store at 2-8°C temperature
2,5-difluoropyridine is a useful building block for the synthesis of various pharmaceutical compounds, such as dual orexin receptor antagonist MK-6096, interleukin receptor associated kinases (IRAK) inhibitors, and TARP γ-8-dependent AMPA receptor antagonist (TDAA), etc..
Removal of fluorine from and introduction of fluorine into polyhalopyridines: An exercise in nucleophilic hetarenic substitution. [1]
Design and optimization of selective protein kinase C θ (PKCθ) inhibitors for the treatment of autoimmune diseases. [2]
Unusual pyrimidine participation: efficient stereoselective synthesis of potent dual orexin receptor antagonist MK-6096. [3]
Discovery of the First α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8. [4]
References:
[1] C.Bobbio, et al, Chem. Eur. J., 2005, 11(6), pp 1903-1910.
[2] J.M.Jimenez, et al, J. Med. Chem., 2013, 56(5), pp 1799-1810.
[3] J.Y.Chung, et al, Org. Lett., 2014, 16(22), pp 5890-5893.
[4] K.M.Gardinier, et al, J. Med. Chem., 2016, 59(10), pp 4753-4768.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H226,H315,H319,H335
P261,P305+P351+P338
2933399990
UN 1993 3/PG III

1. Product Specification
2. Safety Data Sheet
Please inquire for pricing and availability of this product by writing email to sales@kumidas.com.