2-bromo-5-fluoropyridine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
5-fluoro-2-bromopyridine,2-bromanyl-5-fluoranyl-pyridine
Fluorinated Building Blocks
KUMI1F62
41404-58-4
MFCD00234011
2783171
1561456
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Boiling Point
Melting Point
Packaging
Storage
2-bromo-5-fluoropyridine
C5H3BrFN
175.99
≥98%
Colorless to Light-yellow Liquid or Solid
80-83°C/44 mmHg
28-29°C
10g,25g,50g,100g and 500g
Store at room temperature
2-bromo-5-fluoropyridine is a fluorinated pyridine building block in the synthesis of various pharamceutical compounds.
Synthesis of 4-carboxy-4-pyridylpiperidines through palladium-catalyzed α-arylation of esters. [1]
Reactivity of several deactivated 3-aminobenzo[b]thiophenes in the Buchwald–Hartwig C–N coupling. Scope and limitations. [2]
Platinum Complex as a Nanomolar Protein Kinase Inhibitor. [3]
Efficient homo-coupling reactions of heterocyclic aromatic bromides catalyzed by Pd(OAc)2 using indium. [4]
2-Aminobenzophenones as a Novel Class of Bradykinin B1 Receptor Antagonists. [5]
Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile. [5]
References:
[1] Y.Wang, et al, Tetrahedron Lett., 2007, 48(7), pp 1191-1193.
[2] M.R.P.Queiroz, et al, Tetrahedron, 2007, 63(52), pp 13000-13005.
[3] D.S.Williams, et al, Inorg. Chem., 2007, 46(8), pp 2944-2946.
[4] K.Lee, et al, Tetrahedaron Lett., 2008, 49(27), pp 4302-4305.
[5] D.S.Su, et al, J. Med. Chem., 2009, 51(13), pp 3946-3952.
[6] J.A.Christopher, et al, J. Med. Chem., 2015, 58(16), pp 6653-6664.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302,H315,H319,H335
P261,P305+P351+P338
2933399990
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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