2-Chloro-5-fluorosulfonyl-4-fluorobenzoic acid

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem SID
Reaxys RN

Fluorinated Building Blocks, SuFEx Building Blocks
KUMI2F46
1644451-41-1
 
329772634

image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay(Analysis Method)
Appearance
Melting Point
Packaging
Storage
2-Chloro-5-fluorosulfonyl-4-fluorobenzoic acid
C7H3ClF2O4S
256.61
≥95.0%(HPLC)
Solid
160-165°C
1g,5g,10g,50g and 100g
Store at room temperature
Sulfonyl fluorides (SFs) have recently emerged as a promising warhead for the targeted covalent modification of proteins in drug discovery and Post-polymerization modification(PPM) in polymer science. Sulfonyl fluoride buidlding blocks can be used as a connector for the assembly of -SO2- linked small molecules with proteins or nucleic acids. This newly-defined click chemistry approach through sulfates is a complimentary approach to using amides and phosphate groups as linkers.
Sulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry. [1]
A study of the reactivity of S(VI)–F containing warheads with nucleophilic amino-acid side chains under physiological conditions. [2]
References:
[1] J.Dong,L.Krasnova,M.G.Finn,K.B.Sharpless, Angew. Chem. Int. Ed., 2014, 53(36), PP 9430-9448.
[2] H.Mukherjee,J.Debreczeni,J.Breed,S.Tentarelli,B.Aquila,J.E.Dowling,A.Whitty,N.P.Grimster, Org.Biomol.Chem., 2017, 15(45), pp 9685-9695.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H314
P280,P305+P351+338,P310

UN 3261 8 / PG II

1. Product Specification
2. Safety Data Sheet
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