2-Fluoro-3-pyridinecarboxylic acid 

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
2-Fluoronicotinic acid 
Fluorinated Building Blocks, F-Labelling Precursors
KUMI1F158
393-55-5
MFCD00040744

PubChem ID

PubChem ID

PubChem ID
96089
3612
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
2-Fluoro-3-pyridinecarboxylic acid 
C6H4FNO2
141.10
98%
White to Off-white Solid
161-165°C
5g,10g,20g,50g,100g,200g and 500g
Store at room temperature
2-Fluoro-3-pyridinecarboxylic acid (also named as 2-Fluoronicotinic acid) is a building block for the synthesis of various pharmaceuticals substances, such as HCV NS5B polymerase inhibitors, BRAFV600E inhibitors, Human Reticulocyte 15-Lipoxygenase-1 inhibitors and [18F]N-(2-(diethylamino)ethyl)-6-fluoronicotinamide used as a PET melanoma imaging radiotracer.
Oxadiazole derivatives as a novel class of antimitotic agents: Synthesis, inhibition of tubulin polymerization, and activity in tumor cell lines. [1]
Discovery of [18F]N-(2-(diethylamino)ethyl)-6-fluoronicotinamide: a melanoma positron emission tomography imaging radiotracer with high tumor to body contrast ratio and rapid renal clearance. [2]
Discovery of Potent and Selective Inhibitors of Human Reticulocyte 15-Lipoxygenase-1. [3]
Pyridine carboxamides: Potent palm site inhibitors of HCV NS5B polymerase. [4]
Design, synthesis and biological evaluation of novel 5-phenyl-1H-pyrazole derivatives as potential BRAFV600E inhibitors. [5]
References:
[1] X.Ouyang, et al, Bioorg. Med. Chem. Lett., 2006, 16(5), pp 1191-1196.
[2] I.Greguric, et al, J. Med. Chem., 2009, 52(17), pp 5299-5302.
[3] G.Rai, et al, J. Med. Chem., 2010, 53(20), pp 7392-7404.
[4] C.C.Cheng, et al, ACS Med. Chem. Lett., 2010, 1(9), pp 466-471.
[5] S.F.Wang, et al, Bioorg. Med. Chem., 2014, 22(21), pp 6201-6208.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H315,H319,H335
P261,P305+P351+P338
2933399990
NONH for all modes of transport.

1. Product Specification
2. Safety Data Sheet
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