2-Fluoro-6-iodobenzonitrile

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
2-Cyano-3-fluoro-1-iodobenezne
Fluorinated Building Blocks
KUMI1F137
79544-29-9
MFCD00015478
522722
4971873
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
2-Fluoro-6-iodobenzonitrile
C7H3FIN
247.01
≥98%(HPLC)
White to Slightly Pale Yellow Solid
49-53°C
5g,10g,20g,50g,100g,200g and 500g
Store at room temperature
2-Fluoro-6-iodobenzonitrile is a useful fluorinated building block for the synthesis of multi-targeted receptor tyrosine kinases (RTK) inhibitors, such as Linifanib (ABT-869).
Direct synthesis of 2,4‐diaminoquinazolines from 2‐fluorobenzonitriles. [1]
The Discovery and Development of a Safe, Practical Synthesis of ABT-869. [2]
Discovery of novel anti-angiogenesis agents. Part 6: Multi-targeted RTK inhibitors. [3]
References:
[1] J.B.Hynes, et al, J. Heterocycl. Chem., 1988, 25, pp 1173-1177.
[2] A.W.Kruger, et al, Org. Process Res. Dev., 2009, 13(6), pp 1419-1425.
[3] L.Zhang, et al, Eur. J. Med. Chem., 2017, 127, pp 275-285.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H302,H312,H332
P280
292690709000
NONH for all modes of transport

1. Product Specification
2. Safety Data Sheet
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