(2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
1-[(2R,3R)-2-(2,4-difluorophenyl)-2,3-dihydroxybutyl]-1H-[1,2,4]triazole
Fluorinated Building Blocks
KUMI2F51
133775-25-4
MFCD28902278
10286074
5444082
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay(Analysis Method)
Appearance
Melting Point
Packaging
Storage
(2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol
C12H13F2N3O2
269.25
≥96%(HPLC)
Colorless to White Solid
114-117°C
1g,5g,10g,25g,50g,100g,250g,500g and 1kg
Store at room temperature
(2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol is a pharmaceutically useful fluorinated building block in the synthesis of triazole and imidazole type compounds used as antifungal therapeutic agents, typically for the end preparation of Efinaconzaole.
Optically active antifungal azoles. I. Synthesis and antifungal activity of (2R,3R)-2-(2,4-difluorophenyl)-3-mercapto-1-(1H-1,2,4-triazol-1-yl)-2-b utanol and its stereoisomers. [1]
Discovery of novel indazole-linked triazoles as antifungal agents. [2] 
The Process Development of Ravuconazole: An Efficient Multikilogram Scale Preparation of an Antifungal Agent. [3]
Synthesis and Activity of Novel Indole Linked Triazole Derivatives as Antifungal Agents. [4] 
An enantioselective synthesis of the key intermediate for triazole antifungal agents; Application to the catalytic asymmetric synthesis of efinaconazole.[5]
References:
[1] A.Tasaka, et al, Chem. Pharm. Bull. (Tokyo), 1993, 41(6), pp 1035-1042.
[2] J.S.Park, et al, Bioorg. Med. Chem. Lett., 2007, 17(12), pp 3486-3490.
[3] J.Pesti, et al, Org. Process Res. Dev., 2009, 13(4), pp 716-728.
[4] Y.Na, et al, Bull. K. Chem. Soc., 2010, 31(11), pp 3467-3470.
[5] K.Tamura, et al, J. Org. Chem., 2014, 79(7), pp 3272-3278.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H317,H319
280,P305+P351+P338

NONH for all modes of transport

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