(2R,3S)-2-(2,4-difluorophenyl)-3-methyl-2-[(1H-1,2,4-triazole-1-yl)methyl]oxirane is a pharmaceutically useful fluorinated building block in the synthesis of triazole and imidazole type compounds used as antifungal therapeutic agents, typically for the end preparation of Efinaconzaole.
Optically active antifungal azoles. I. Synthesis and antifungal activity of (2R,3R)-2-(2,4-difluorophenyl)-3-mercapto-1-(1H-1,2,4-triazol-1-yl)-2-b utanol and its stereoisomers.
Optically active antifungal azoles. IV. Synthesis and antifungal activity of (2R,3R)-3-Azolyl-2-(substituted phenyl)-1(1H-1,2,4-triazol-1-yl)-2-butanols. 
Discovery of novel indazole-linked triazoles as antifungal agents. 
Discovery of a novel broad-spectrum antifungal agent derived from albaconazole. 
Improved laboratory synthesis of YC-071, a potent azole antifungal agent.