(2R,3S)-2-(2,4-difluorophenyl)-3-methyl-2-[(1H-1,2,4-triazole-1-yl)methyl]oxirane

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN

Fluorinated Building Blocks
KUMI2F50
127000-90-2
MFCD09833867
10131191
4908890
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay(Analysis Method)
Appearance
Melting Point
Packaging
Storage
1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole
C12H11F2N3O
251.24
≥98%(HPLC)
White to Off-white Solid
91-92°C
5g,10g,25g,50g,100g,250g,500g and 1kg
Store at room temperature
(2R,3S)-2-(2,4-difluorophenyl)-3-methyl-2-[(1H-1,2,4-triazole-1-yl)methyl]oxirane is a pharmaceutically useful fluorinated building block in the synthesis of triazole and imidazole type compounds used as antifungal therapeutic agents, typically for the end preparation of Efinaconzaole.
Optically active antifungal azoles. I. Synthesis and antifungal activity of (2R,3R)-2-(2,4-difluorophenyl)-3-mercapto-1-(1H-1,2,4-triazol-1-yl)-2-b utanol and its stereoisomers. [1]
Optically active antifungal azoles. IV. Synthesis and antifungal activity of (2R,3R)-3-Azolyl-2-(substituted phenyl)-1(1H-1,2,4-triazol-1-yl)-2-butanols. [2]
Discovery of novel indazole-linked triazoles as antifungal agents. [3] 
Discovery of a novel broad-spectrum antifungal agent derived from albaconazole. [4] 
Improved laboratory synthesis of YC-071, a potent azole antifungal agent. [5]
References:
[1] A.Tasaka, et al, Chem. Pharm. Bull. (Tokyo), 1993, 41(6), pp 1035-1042.
[2] A.Tasaka, et al, Chem. Pharm. Bull. (Tokyo), 1995, 43(3), pp 432-440.
[3] J.S.Park, et al, Bioorg. Med. Chem. Lett., 2007, 17(12), pp 3486-3490.
[4] R.Guillon, et al, ACS Med. Chem. Lett., 2013, 4(2), pp 288-292.
[5] Y.Zhang, et al, J. Chem. Res., 2017, 41(4), pp 241-245.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H317,H319
280,P305+P351+P338

NONH for all modes of transport

Please inquire for pricing and availability of this product by writing email to sales@kumidas.com.