3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl bromide

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
2-(5-bromo-2-methyl-benzyl)-5-(4-fluorophenyl)thiophene
Fluorinated Building Blocks
KUMI1F55
1030825-20-7
MFCD21496340
46930432
18362680
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay(Analysis Method)
Appearance
Melting Point
Packaging
Storage
3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl bromide
C18H14BrFS
361.28
≥96%(HPLC)
Light-yellow to Yellow Solid
101-103°C
1g,5g,10g,25g,50g,100g,250g,500g and 1kg
Store at room temperature
3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl bromide is a pharmaceutically useful fluorinated building block in the synthesis of sodium-dependent glucose transporter (SGLT) inhibitors, typically used as Canagliflozin intermediate II.
Discovery of canagliflozin, a novel C-glucoside with thiophene ring, as sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes mellitus (1). [1]
β-Selective C-Arylation of Diisobutylaluminum Hydride Modified 1,6-Anhydroglucose: Synthesis of Canagliflozin without Recourse to Conventional Protecting Groups. [2] 
Copper-Catalyzed Arylation of Benzylic C–H bonds with Alkylarenes as the Limiting Reagents. [3]
References:
[1] S. Nomura, et al, J. Med. Chem., 2010, 53(17), pp 6355-6360.
[2] J.P.Henschke, et al, J. Org. Chem., 2015, 80(10), pp 5189-5195.
[3] W.Zhang, et al, J. Am. Chem. Soc., 2017, 139(23), pp 7709-7712.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H302,H318,H413
P280,P305+P351+P338

NONH for all modes of transport

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