3,6-difluoropyrazine-2-carbonitrile

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
3,6-difluoro-2-cyanopyrazine, 3,6-difluoropyrazinonitrile
Fluorinated Building Blocks
KUMI2F84
356783-28-3
MFCD22199270
22662829
14085504
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
3,6-difluoropyrazine-2-carbonitrile
C5HF2N3
141.08
≥97%(HPLC)
White to Yellow Solid
56-57°C
5g,10g,25g,50g,100g,500g and 1kg
Store at room temperature
3,6-difluoropyrazine-2-carbonitrile is a useful fluorinated building block and production intermediate in the synthesis of 6-fluoro-3- hydroxypyrazine-2-carboxamide commercially named favipiravir, which is a unique viral RNA Polymerase inhibitor for the treatment of Influenza, acting on viral genetic copying to prevent its reproduction.
Synthesis and crystal structure of 6-fluoro-3-hydroxypyrazine-2-carboxamide. [1]
A practical and step-economic route to Favipiravir. [2]
References:
[1] F.Shi, et al, Drug Discov. Ther., 2014, 8(3), pp 117-120.
[2] F.Lin, et al, Chem. Pap., 2017, 71(11), pp 2153-2158.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Danger
H301,H311,H331
P260,P280,P301+P310,P302+P352,P304+P340,P361

UN 2811 6.1/PG III
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2. Safety Data Sheet
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