3-(bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methylbromide
Fluorinated Building Blocks
KUMI1F60
154057-56-4
MFCD09031391
29927785
5822108
image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay
Appearance
Melting Point
Packaging
Storage
3-(bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline
C19H15BrFN
356.24
≥98%(HPLC)
Colorless to Pale-yellow Solid
138-140°C
5g,10g,25g,50g,100g and 500g
Store at room temperature
3-(bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline is a fluorinated building block in the synthesis of various pharamceutical compounds, e.g. pitavastatin and its pharmaceutical acceptable salts.
A novel enantioselective synthesis of HMG Co-A reductase inhibitor NK-104 and a related compound. [1]
The use of a lactonized statin side-chain precursor in a concise and efficient assembly of pitavastatin. [2]
Highly stereoselective formal synthesis of rosuvastatin and pitavastatin through Julia-Kocienski olefination using the lactonized statin side-chain precursor. [3]
Synthesis, characterization of 3-(bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline and its crystal structure. [4]
Synthesis, characterization, crystal structure, in-vitro anti-inflammatory and molecular docking studies of 5-mercapto-1-substituted tetrazole incorporated quinoline derivative. [5]
References:
[1] T.Minami, et al, Tetrahedron Lett., 1992, 33(49), pp 7525-7526.
[2] J.Fabris, et al, Synth., 2012, 44(11), pp 1700-1710.
[3] J.Fabris, et al, Synth., 2014, 46(17), pp 2333-2346.
[4] J.Y.Xu, et al, Asian J. Chem., 2014, 26(22), pp 7587-7590.
[5] K.Sureshkumar, et al, J. Mol. Struct., 2017, 1146(15), pp 314-323.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H317,H319
P280,P305+P351+P338

NONH for all modes of transport

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