3-chloro-2,4-difluorobenzoic acidis a halogenated building blocks for the synthesis of various pharmaceutial compounds. Such as 2,4-Difluoro-3,5-dichlorobenzoic acid as a key intermediate for preparing quinolone-3-carboxylic acids.
Discovery of Novel DNA Gyrase Inhibiting Spiropyrimidinetriones: Benzisoxazole Fusion with N-Linked Oxazolidinone Substituents Leading to a Clinical Candidate (ETX0914).
An efficient synthesis of 2,4-difluoro-3,5-dichlorobenzoic acid.
 G.S.Basarab, et al, J. Med. Chem., 2015, 58(5), pp 6264-6282.
 W.Zhou, et al, J. Chem. Res., 2015, 39(5), pp 277-278.