3-chloro-2-fluoro-4-(trifluoromethyl)pyridine

Synonym
Product Category
Product Code
CAS Number
MDL Number
Pubchem CID
Reaxys RN
3-chloranyl-2-fluoranyl-4-(trifluoromethyl)pyridine
Fluorinated Building Blocks
KUMI4F19
1227496-80-1
MFCD16610405
56604230

image-155171-Trimethyl(trifluoromethyl)silane_reagent.png
Chemical Name
Molecular Formula
Molecular Weight
Assay(Analysis Method)
Appearance
Melting Point
Packaging
Storage
3-chloro-2-fluoro-4-(trifluoromethyl)pyridine
C6H2ClF4N
199.53
≥98%(GC)
Colorless Liquid
50-55°C/11 mmHg
5g,10g,50g,100g,200g and 500g
Store at 2-8°C temperature
3-chloro-2-fluoro-4-(trifluoromethyl)pyridine is a useful fluorinated building block for the synthesis of various substituted pyridine compounds in pharmaceutical and agrochemical.  for example, it participates in the synthesis of 2,3-difluoro-5-(trifluoromethyl)pyridine, which is an important chemical intermediate in the preparation of herbicides.
Regioselective Substitution in Aromatic Six-Membered Nitrogen Heterocycles. [1]
Origin of enantiomeric selectivity in the aryloxyphenoxypropionic acid class of herbicidal acetyl coenzyme A carboxylase (ACCase) inhibitors. [2]
Catalytic fluorination of 2-chloropyridine over metal oxide catalysts in gas phase in the presence of HF. [3]
References:
[1] D.L.Comins, et al, Adv. Heterocycl. Chem., 1988, 44, pp 199-267.
[2] J.A.Turner, et al. A. Agric. Food Chem., 2002, 50(16), pp 4554-4566.
[3] C.Cochon, et al, Appl. Catal. A., 2012, 413-414, pp 149-156.
Signal Word
Hazard Statements
Precautionary Statements
HS Code
RIDADR
Legal Information
Warning
H226,H315,H319,H335
P261,P305+P351+P338
2933399990
UN 1993 3/PG III

1. Product Specification
2. Safety Data Sheet
Please inquire for pricing and availability of this product by writing email to sales@kumidas.com.