3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine is a useful fluorinated building block for the synthesis of various substituted pyridine compounds in pharmaceutical and agrochemical. for example, it participates in the synthesis of 2,3-difluoro-5-(trifluoromethyl)pyridine, which is an important chemical intermediate in the preparation of herbicides.
Regioselective Substitution in Aromatic Six-Membered Nitrogen Heterocycles.
Origin of enantiomeric selectivity in the aryloxyphenoxypropionic acid class of herbicidal acetyl coenzyme A carboxylase (ACCase) inhibitors. 
Catalytic fluorination of 2-chloropyridine over metal oxide catalysts in gas phase in the presence of HF.